p38 MAPK and JNK Antagonistically Control Senescence and Cytoplasmic p16INK4A Expression in Doxorubicin-Treated Endothelial Progenitor Cells

Paolo Spallarossa; Paola Altieri; Chiara Barisione; Mario Passalacqua; Concetta Aloi; Giuseppina Fugazza; Francesco Frassoni; Marina Podestà; Marco Canepa; Giorgio Ghigliotti; Claudio Brunelli

doi:10.1371/journal.pone.0015583

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Peer-reviewed

Research Article

p38 MAPK and JNK Antagonistically Control Senescence and Cytoplasmic p16INK4A Expression in Doxorubicin-Treated Endothelial Progenitor Cells

Paolo Spallarossa ,

Contributed equally to this work with: Paolo Spallarossa, Paola Altieri

Affiliation Division of Cardiology, Research Center of Cardiovascular Biology, University of Genova, Genova, Italy
⨯
Paola Altieri ,

Contributed equally to this work with: Paolo Spallarossa, Paola Altieri

* E-mail: paola.altieri@unige.it

Affiliation Division of Cardiology, Research Center of Cardiovascular Biology, University of Genova, Genova, Italy
⨯
Chiara Barisione,

Affiliation Division of Cardiology, Research Center of Cardiovascular Biology, University of Genova, Genova, Italy
⨯
Mario Passalacqua,

Affiliation Biochemistry Section, Department of Experimental Medicine, Centre of Excellence for Biomedical Research, University of Genova, Genova, Italy
⨯
Concetta Aloi,

Affiliation Division of Cardiology, Research Center of Cardiovascular Biology, University of Genova, Genova, Italy
⨯
Giuseppina Fugazza,

Affiliation Laboratory of Cytogenetics, Department of Internal Medicine, University of Genova, Genova, Italy
⨯
Francesco Frassoni,

Affiliation Stem Cell and Cell Therapy Centre, San Martino Hospital, Genova, Italy
⨯
Marina Podestà,

Affiliation 2nd Division, Department of Hematology, S. Martino Hospital, Genova, Italy
⨯
Marco Canepa,

Affiliation Division of Cardiology, Research Center of Cardiovascular Biology, University of Genova, Genova, Italy
⨯
Giorgio Ghigliotti,

Affiliation Division of Cardiology, Research Center of Cardiovascular Biology, University of Genova, Genova, Italy
⨯
Claudio Brunelli

Affiliation Division of Cardiology, Research Center of Cardiovascular Biology, University of Genova, Genova, Italy
⨯

p38 MAPK and JNK Antagonistically Control Senescence and Cytoplasmic p16INK4A Expression in Doxorubicin-Treated Endothelial Progenitor Cells

Paolo Spallarossa,
Paola Altieri,
Chiara Barisione,
Mario Passalacqua,
Concetta Aloi,
Giuseppina Fugazza,
Francesco Frassoni,
Marina Podestà,
Marco Canepa,
Giorgio Ghigliotti

Published: December 20, 2010
https://doi.org/10.1371/journal.pone.0015583

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