Deletion of CDKAL1 Affects Mitochondrial ATP Generation and First-Phase Insulin Exocytosis

Mica Ohara-Imaizumi; Masashi Yoshida; Kyota Aoyagi; Taro Saito; Tadashi Okamura; Hitoshi Takenaka; Yoshihiro Akimoto; Yoko Nakamichi; Rieko Takanashi-Yanobu; Chiyono Nishiwaki; Hayato Kawakami; Norihiro Kato; Shin-ichi Hisanaga; Masafumi Kakei; Shinya Nagamatsu

doi:10.1371/journal.pone.0015553

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Open Access

Peer-reviewed

Research Article

Deletion of CDKAL1 Affects Mitochondrial ATP Generation and First-Phase Insulin Exocytosis

Mica Ohara-Imaizumi,

Affiliation Department of Biochemistry, Kyorin University School of Medicine, Tokyo, Japan
⨯
Masashi Yoshida,

Affiliation First Department of Medicine, Saitama Medical Center, Jichi Medical University School of Medicine, Saitama, Japan
⨯
Kyota Aoyagi,

Affiliation Department of Biochemistry, Kyorin University School of Medicine, Tokyo, Japan
⨯
Taro Saito,

Affiliation Department of Biological Sciences, Tokyo Metropolitan University, Tokyo, Japan
⨯
Tadashi Okamura,

Affiliation Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
⨯
Hitoshi Takenaka,

Affiliation Department of Biochemistry, Kyorin University School of Medicine, Tokyo, Japan
⨯
Yoshihiro Akimoto,

Affiliation Department of Anatomy, Kyorin University School of Medicine, Tokyo, Japan
⨯
Yoko Nakamichi,

Affiliation Department of Biochemistry, Kyorin University School of Medicine, Tokyo, Japan
⨯
Rieko Takanashi-Yanobu,

Affiliation Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
⨯
Chiyono Nishiwaki,

Affiliation Department of Biochemistry, Kyorin University School of Medicine, Tokyo, Japan
⨯
Hayato Kawakami,

Affiliation Department of Anatomy, Kyorin University School of Medicine, Tokyo, Japan
⨯
Norihiro Kato,

Affiliation Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
⨯
Shin-ichi Hisanaga,

Affiliation Department of Biological Sciences, Tokyo Metropolitan University, Tokyo, Japan
⨯
Masafumi Kakei,

Affiliation First Department of Medicine, Saitama Medical Center, Jichi Medical University School of Medicine, Saitama, Japan
⨯
Shinya Nagamatsu

* E-mail: shinya@ks.kyorin-u.ac.jp

Affiliation Department of Biochemistry, Kyorin University School of Medicine, Tokyo, Japan
⨯

Deletion of CDKAL1 Affects Mitochondrial ATP Generation and First-Phase Insulin Exocytosis

Mica Ohara-Imaizumi,
Masashi Yoshida,
Kyota Aoyagi,
Taro Saito,
Tadashi Okamura,
Hitoshi Takenaka,
Yoshihiro Akimoto,
Yoko Nakamichi,
Rieko Takanashi-Yanobu,
Chiyono Nishiwaki

Published: December 9, 2010
https://doi.org/10.1371/journal.pone.0015553

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Insulin
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Glucose
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Exocytosis
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Cell fusion
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Membrane potential
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