Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

• Oliver N. F. King ,

  Contributed equally to this work with: Oliver N. F. King, Xuan Shirley Li, Masaaki Sakurai

  Affiliation Structural Genomics Consortium, University of Oxford, Headington, United Kingdom

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• Xuan Shirley Li ,

  Contributed equally to this work with: Oliver N. F. King, Xuan Shirley Li, Masaaki Sakurai

  Affiliation Department of Biochemistry, University of Oxford, Oxford, United Kingdom

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• Masaaki Sakurai ,

  Contributed equally to this work with: Oliver N. F. King, Xuan Shirley Li, Masaaki Sakurai

  Current address: Mitsubishi Tanabe Pharma Corporation, Aoba-ku, Yokohama, Japan

  Affiliation National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Akane Kawamura ,

  ¶These authors also contributed equally to this work.

  Affiliation Department of Chemistry and the Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, United Kingdom

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• Nathan R. Rose ,

  ¶These authors also contributed equally to this work.

  Affiliation Department of Chemistry and the Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, United Kingdom

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• Stanley S. Ng,

  Affiliation Structural Genomics Consortium, University of Oxford, Headington, United Kingdom

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• Amy M. Quinn,

  Affiliation National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Ganesha Rai,

  Affiliation National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Bryan T. Mott,

  Affiliation National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Paul Beswick,

  Current address: Almirall S.A., Barcelona, Spain

  Affiliation Structural Genomics Consortium, University of Oxford, Headington, United Kingdom

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• Robert J. Klose,

  Affiliation Department of Biochemistry, University of Oxford, Oxford, United Kingdom

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• Udo Oppermann,

  Affiliation Structural Genomics Consortium, University of Oxford, Headington, United Kingdom

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• Ajit Jadhav,

  Affiliation National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Tom D. Heightman,

  Affiliation Structural Genomics Consortium, University of Oxford, Headington, United Kingdom

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• David J. Maloney,

  Affiliation National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Christopher J. Schofield,

  Affiliation Department of Chemistry and the Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, United Kingdom

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•  [ ... ],
• Anton Simeonov

  * E-mail: asimeono@mail.nih.gov

  Affiliation National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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