PARP1 Gene Knock-Out Increases Resistance to Retinal Degeneration without Affecting Retinal Function

Ayse Sahaboglu; Naoyuki Tanimoto; Jasvir Kaur; Javier Sancho-Pelluz; Gesine Huber; Edda Fahl; Blanca Arango-Gonzalez; Eberhart Zrenner; Per Ekström; Hubert Löwenheim; Mathias Seeliger; François Paquet-Durand

doi:10.1371/journal.pone.0015495

Loading metrics

Open Access

Peer-reviewed

Research Article

PARP1 Gene Knock-Out Increases Resistance to Retinal Degeneration without Affecting Retinal Function

Ayse Sahaboglu,

Affiliation Division of Experimental Ophthalmology, Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany
⨯
Naoyuki Tanimoto,

Affiliation Ocular Neurodegeneration Research Group, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany
⨯
Jasvir Kaur,

Affiliation Division of Experimental Ophthalmology, Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany
⨯
Javier Sancho-Pelluz,

Current address: Department of Ophthalmology, Columbia University, Edward S. Harkness Eye Institute Research Annex, New York, New York, United States of America

Affiliation Division of Experimental Ophthalmology, Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany
⨯
Gesine Huber,

Affiliation Ocular Neurodegeneration Research Group, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany
⨯
Edda Fahl,

Affiliation Ocular Neurodegeneration Research Group, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany
⨯
Blanca Arango-Gonzalez,

Affiliation Division of Experimental Ophthalmology, Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany
⨯
Eberhart Zrenner,

Affiliation Division of Experimental Ophthalmology, Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany
⨯
Per Ekström,

Affiliation Department of Ophthalmology, Clinical Sciences Lund, University of Lund, Lund, Sweden
⨯
Hubert Löwenheim,

Affiliation Otolaryngology Department, University of Tübingen, Tübingen, Germany
⨯
Mathias Seeliger,

Affiliation Ocular Neurodegeneration Research Group, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany
⨯
François Paquet-Durand

* E-mail: francois.paquet-durand@klinikum.uni-tuebingen.de

Affiliation Division of Experimental Ophthalmology, Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany
⨯

PARP1 Gene Knock-Out Increases Resistance to Retinal Degeneration without Affecting Retinal Function

Ayse Sahaboglu,
Naoyuki Tanimoto,
Jasvir Kaur,
Javier Sancho-Pelluz,
Gesine Huber,
Edda Fahl,
Blanca Arango-Gonzalez,
Eberhart Zrenner,
Per Ekström,
Hubert Löwenheim

Published: November 23, 2010
https://doi.org/10.1371/journal.pone.0015495

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Photoreceptors
Is the Subject Area "Photoreceptors" applicable to this article?

Thanks for your feedback.
Retina
Is the Subject Area "Retina" applicable to this article?

Thanks for your feedback.
Cell death
Is the Subject Area "Cell death" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Retinal degeneration
Is the Subject Area "Retinal degeneration" applicable to this article?

Thanks for your feedback.
Retinitis pigmentosa
Is the Subject Area "Retinitis pigmentosa" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Tomography
Is the Subject Area "Tomography" applicable to this article?

Thanks for your feedback.