The ERAD Inhibitor Eeyarestatin I Is a Bifunctional Compound with a Membrane-Binding Domain and a p97/VCP Inhibitory Group

Qiuyan Wang; Bidhan A. Shinkre; Jin-gu Lee; Marc A. Weniger; Yanfen Liu; Weiping Chen; Adrian Wiestner; William C. Trenkle; Yihong Ye

doi:10.1371/journal.pone.0015479

Loading metrics

Open Access

Peer-reviewed

Research Article

The ERAD Inhibitor Eeyarestatin I Is a Bifunctional Compound with a Membrane-Binding Domain and a p97/VCP Inhibitory Group

Qiuyan Wang,

Affiliation Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Bidhan A. Shinkre,

Affiliation Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Jin-gu Lee,

Affiliation Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Marc A. Weniger,

Affiliation Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Yanfen Liu,

Affiliation Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Weiping Chen,

Affiliation The Genomics Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Adrian Wiestner,

Affiliation Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
William C. Trenkle,

Affiliation Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Yihong Ye

* E-mail: yihongy@mail.nih.gov

Affiliation Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

The ERAD Inhibitor Eeyarestatin I Is a Bifunctional Compound with a Membrane-Binding Domain and a p97/VCP Inhibitory Group

Qiuyan Wang,
Bidhan A. Shinkre,
Jin-gu Lee,
Marc A. Weniger,
Yanfen Liu,
Weiping Chen,
Adrian Wiestner,
William C. Trenkle,
Yihong Ye

Published: November 12, 2010
https://doi.org/10.1371/journal.pone.0015479

Reader Comments (2)

Post a new comment on this article

1 Response

25 Jan 2011
15:35 GMT
Most Recent

Fig5e Posted by Simonhoer on 24 Jan 2011 at 17:28 GMT

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Endoplasmic reticulum
Is the Subject Area "Endoplasmic reticulum" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Homeostasis
Is the Subject Area "Homeostasis" applicable to this article?

Thanks for your feedback.
Adenosine triphosphatase
Is the Subject Area "Adenosine triphosphatase" applicable to this article?

Thanks for your feedback.
Immunoblotting
Is the Subject Area "Immunoblotting" applicable to this article?

Thanks for your feedback.
293T cells
Is the Subject Area "293T cells" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Fluorescence imaging
Is the Subject Area "Fluorescence imaging" applicable to this article?

Thanks for your feedback.