Self-Renewal of Acute Lymphocytic Leukemia Cells Is Limited by the Hedgehog Pathway Inhibitors Cyclopamine and IPI-926

Tara L. Lin; Qiuju H. Wang; Patrick Brown; Craig Peacock; Akil A. Merchant; Sarah Brennan; Evan Jones; Karen McGovern; D. Neil Watkins; Kathleen M. Sakamoto; William Matsui

doi:10.1371/journal.pone.0015262

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Peer-reviewed

Research Article

Self-Renewal of Acute Lymphocytic Leukemia Cells Is Limited by the Hedgehog Pathway Inhibitors Cyclopamine and IPI-926

Tara L. Lin ,

* E-mail: tlin@lsuhsc.edu (TLL); matsuwi@jhmi.edu (WM)

Affiliation Section of Hematology and Oncology, Department of Internal Medicine, LSU Health Sciences Center, New Orleans, Louisiana, United States of America
⨯
Qiuju H. Wang,

Affiliation Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Patrick Brown,

Affiliation Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Craig Peacock,

Affiliation Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Akil A. Merchant,

Affiliation Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Sarah Brennan,

Affiliation Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Evan Jones,

Affiliation Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Karen McGovern,

Affiliation Infinity Pharmaceuticals, Cambridge, Massachusetts, United States of America
⨯
D. Neil Watkins,

Affiliation Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Kathleen M. Sakamoto,

Affiliation Gwynne Hazen Cherry Memorial Laboratories, Department of Pediatrics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
⨯
William Matsui

* E-mail: tlin@lsuhsc.edu (TLL); matsuwi@jhmi.edu (WM)

Affiliation Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯

Self-Renewal of Acute Lymphocytic Leukemia Cells Is Limited by the Hedgehog Pathway Inhibitors Cyclopamine and IPI-926

Tara L. Lin,
Qiuju H. Wang,
Patrick Brown,
Craig Peacock,
Akil A. Merchant,
Sarah Brennan,
Evan Jones,
Karen McGovern,
D. Neil Watkins,
Kathleen M. Sakamoto

Published: December 28, 2010
https://doi.org/10.1371/journal.pone.0015262

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