Platelet-Activating Factor Induces TLR4 Expression in Intestinal Epithelial Cells: Implication for the Pathogenesis of Necrotizing Enterocolitis

Antoine Soliman; Kathrin S. Michelsen; Hisae Karahashi; Jing Lu; Fan Jing Meng; Xiaowu Qu; Timothy R. Crother; Shervin Rabizadeh; Shuang Chen; Michael S. Caplan; Moshe Arditi; Tamas Jilling

doi:10.1371/journal.pone.0015044

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Peer-reviewed

Research Article

Platelet-Activating Factor Induces TLR4 Expression in Intestinal Epithelial Cells: Implication for the Pathogenesis of Necrotizing Enterocolitis

Antoine Soliman,

Affiliation Department of Pediatrics, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America
⨯
Kathrin S. Michelsen,

Affiliation Department of Pediatrics, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America
⨯
Hisae Karahashi,

Affiliation Department of Pediatrics, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America
⨯
Jing Lu,

Affiliations Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America, Evanston Northwestern Healthcare Research Institute, Evanston, Illinois, United States of America
⨯
Fan Jing Meng,

Affiliation Evanston Northwestern Healthcare Research Institute, Evanston, Illinois, United States of America
⨯
Xiaowu Qu,

Affiliation Evanston Northwestern Healthcare Research Institute, Evanston, Illinois, United States of America
⨯
Timothy R. Crother,

Affiliation Department of Pediatrics, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America
⨯
Shervin Rabizadeh,

Affiliation Department of Pediatrics, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America
⨯
Shuang Chen,

Affiliation Department of Pediatrics, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America
⨯
Michael S. Caplan,

Affiliations Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America, Evanston Northwestern Healthcare Research Institute, Evanston, Illinois, United States of America
⨯
Moshe Arditi ,

* E-mail: moshe.arditi@cshs.org

Affiliation Department of Pediatrics, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America
⨯
Tamas Jilling

Affiliations Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America, Evanston Northwestern Healthcare Research Institute, Evanston, Illinois, United States of America
⨯

Platelet-Activating Factor Induces TLR4 Expression in Intestinal Epithelial Cells: Implication for the Pathogenesis of Necrotizing Enterocolitis

Antoine Soliman,
Kathrin S. Michelsen,
Hisae Karahashi,
Jing Lu,
Fan Jing Meng,
Xiaowu Qu,
Timothy R. Crother,
Shervin Rabizadeh,
Shuang Chen,
Michael S. Caplan

Published: October 15, 2010
https://doi.org/10.1371/journal.pone.0015044

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Gastrointestinal tract
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Toll-like receptors
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Epithelial cells
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Gene expression
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Transcription factors
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Immune receptor signaling
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Transfection
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