The CD40-Autophagy Pathway Is Needed for Host Protection Despite IFN-Γ-Dependent Immunity and CD40 Induces Autophagy via Control of P21 Levels

Jose-Andres C. Portillo; Genevieve Okenka; Erin Reed; Angela Subauste; Jennifer Van Grol; Katrin Gentil; Masaaki Komatsu; Keiji Tanaka; Gary Landreth; Beth Levine; Carlos S. Subauste

doi:10.1371/journal.pone.0014472

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Research Article

The CD40-Autophagy Pathway Is Needed for Host Protection Despite IFN-Γ-Dependent Immunity and CD40 Induces Autophagy via Control of P21 Levels

Jose-Andres C. Portillo,

Affiliations Department of Ophthalmology and Visual Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
Genevieve Okenka,

Affiliations Department of Ophthalmology and Visual Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
Erin Reed,

Affiliation Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
Angela Subauste,

Affiliation Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, United States of America
⨯
Jennifer Van Grol,

Affiliations Department of Ophthalmology and Visual Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
Katrin Gentil,

Affiliation Department of Ophthalmology and Visual Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
Masaaki Komatsu,

Affiliation Laboratory for Frontier Science, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
⨯
Keiji Tanaka,

Affiliation Laboratory for Frontier Science, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
⨯
Gary Landreth,

Affiliation Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
Beth Levine,

Affiliation Department of Internal Medicine, Department of Microbiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
⨯
Carlos S. Subauste

* E-mail: carlos.subauste@case.edu

Affiliations Department of Ophthalmology and Visual Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯

The CD40-Autophagy Pathway Is Needed for Host Protection Despite IFN-Γ-Dependent Immunity and CD40 Induces Autophagy via Control of P21 Levels

Jose-Andres C. Portillo,
Genevieve Okenka,
Erin Reed,
Angela Subauste,
Jennifer Van Grol,
Katrin Gentil,
Masaaki Komatsu,
Keiji Tanaka,
Gary Landreth,
Beth Levine

Published: December 31, 2010
https://doi.org/10.1371/journal.pone.0014472

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