T Cell LFA-1 Engagement Induces HuR-Dependent Cytokine mRNA Stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 Signaling Cascade

Vinod S. Ramgolam; Scott D. DeGregorio; Gautham K. Rao; Mark Collinge; Sharmila S. Subaran; Silva Markovic-Plese; Ruggero Pardi; Jeffrey R. Bender

doi:10.1371/journal.pone.0014450

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Research Article

T Cell LFA-1 Engagement Induces HuR-Dependent Cytokine mRNA Stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 Signaling Cascade

Vinod S. Ramgolam,

Affiliation Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, Departments of Medicine (Cardiovascular Medicine) and Immunobiology, Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Scott D. DeGregorio,

Affiliation Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, Departments of Medicine (Cardiovascular Medicine) and Immunobiology, Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Gautham K. Rao,

Affiliation Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, Departments of Medicine (Cardiovascular Medicine) and Immunobiology, Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Mark Collinge,

Affiliation Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, Departments of Medicine (Cardiovascular Medicine) and Immunobiology, Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Sharmila S. Subaran,

Affiliation Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, Departments of Medicine (Cardiovascular Medicine) and Immunobiology, Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Silva Markovic-Plese,

Affiliation Department of Neurology and of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
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Ruggero Pardi,

Affiliation Department of Molecular Pathology, Universitá Vita-Salute School of Medicine, San Raffaele Scientific Institute, Milan, Italy
⨯
Jeffrey R. Bender

* E-mail: jeffrey.bender@yale.edu

Affiliation Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, Departments of Medicine (Cardiovascular Medicine) and Immunobiology, Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯

T Cell LFA-1 Engagement Induces HuR-Dependent Cytokine mRNA Stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 Signaling Cascade

Vinod S. Ramgolam,
Scott D. DeGregorio,
Gautham K. Rao,
Mark Collinge,
Sharmila S. Subaran,
Silva Markovic-Plese,
Ruggero Pardi,
Jeffrey R. Bender

Published: December 29, 2010
https://doi.org/10.1371/journal.pone.0014450

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T cells
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Messenger RNA
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Cytokines
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Immunoprecipitation
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Integrins
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Gene expression
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Transfection
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