α-Galactosylceramide Analogs with Weak Agonist Activity for Human iNKT Cells Define New Candidate Anti-Inflammatory Agents

Gabriel Bricard; Manjunatha M. Venkataswamy; Karl O. A. Yu; Jin S. Im; Rachel M. Ndonye; Amy R. Howell; Natacha Veerapen; Petr A. Illarionov; Gurdyal S. Besra; Qian Li; Young-Tae Chang; Steven A. Porcelli

doi:10.1371/journal.pone.0014374

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Open Access

Peer-reviewed

Research Article

α-Galactosylceramide Analogs with Weak Agonist Activity for Human iNKT Cells Define New Candidate Anti-Inflammatory Agents

Gabriel Bricard,

Affiliation Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Manjunatha M. Venkataswamy,

Affiliation Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Karl O. A. Yu,

Affiliation Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Jin S. Im,

Affiliation Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Rachel M. Ndonye,

Affiliation Department of Chemistry, University of Connecticut, Storrs, Connecticut, United States of America
⨯
Amy R. Howell,

Affiliation Department of Chemistry, University of Connecticut, Storrs, Connecticut, United States of America
⨯
Natacha Veerapen,

Affiliation School of Biosciences, University of Birmingham, Edgbaston, United Kingdom
⨯
Petr A. Illarionov,

Affiliation School of Biosciences, University of Birmingham, Edgbaston, United Kingdom
⨯
Gurdyal S. Besra,

Affiliation School of Biosciences, University of Birmingham, Edgbaston, United Kingdom
⨯
Qian Li,

Current address: McCormick and Company, Inc. Technical Innovation Center, Hunt Valley, Maryland, United States of America

Affiliation Department of Chemistry, National University of Singapore, Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore
⨯
Young-Tae Chang,

Affiliation Department of Chemistry, National University of Singapore, Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore
⨯
Steven A. Porcelli

* E-mail: steven.porcelli@einstein.yu.edu

Affiliations Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯

α-Galactosylceramide Analogs with Weak Agonist Activity for Human iNKT Cells Define New Candidate Anti-Inflammatory Agents

Gabriel Bricard,
Manjunatha M. Venkataswamy,
Karl O. A. Yu,
Jin S. Im,
Rachel M. Ndonye,
Amy R. Howell,
Natacha Veerapen,
Petr A. Illarionov,
Gurdyal S. Besra,
Qian Li

Published: December 17, 2010
https://doi.org/10.1371/journal.pone.0014374

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