Altered Chromosomal Positioning, Compaction, and Gene Expression with a Lamin A/C Gene Mutation

Stephanie K. Mewborn; Megan J. Puckelwartz; Fida Abuisneineh; John P. Fahrenbach; Yuan Zhang; Heather MacLeod; Lisa Dellefave; Peter Pytel; Sara Selig; Christine M. Labno; Karen Reddy; Harinder Singh; Elizabeth McNally

doi:10.1371/journal.pone.0014342

Loading metrics

Open Access

Peer-reviewed

Research Article

Altered Chromosomal Positioning, Compaction, and Gene Expression with a Lamin A/C Gene Mutation

Stephanie K. Mewborn ,

Contributed equally to this work with: Stephanie K. Mewborn, Megan J. Puckelwartz

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Megan J. Puckelwartz ,

Contributed equally to this work with: Stephanie K. Mewborn, Megan J. Puckelwartz

Affiliations Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America, Department of Human Genetics, The University of Chicago, Chicago, Illinois, United States of America
⨯
Fida Abuisneineh,

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
John P. Fahrenbach,

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Yuan Zhang,

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Heather MacLeod,

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Lisa Dellefave,

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Peter Pytel,

Affiliation Department of Pathology, The University of Chicago, Chicago, Illinois, United States of America
⨯
Sara Selig,

Affiliation Molecular Medicine Laboratory, Rambam Health Care Campus and Rappaport Faculty of Medicine and Research Institute, Technion - Israel Institute of Technology, Haifa, Israel
⨯
Christine M. Labno,

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Karen Reddy,

Current address: School of Medicine, Johns Hopkins, Baltimore, Maryland, United States of America

Affiliation Howard Hughes Medical Institute and Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois, United States of America
⨯
Harinder Singh,

Affiliation Howard Hughes Medical Institute and Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois, United States of America
⨯
Elizabeth McNally

* E-mail: emcnally@uchicago.edu

Affiliations Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America, Department of Human Genetics, The University of Chicago, Chicago, Illinois, United States of America
⨯

Altered Chromosomal Positioning, Compaction, and Gene Expression with a Lamin A/C Gene Mutation

Stephanie K. Mewborn,
Megan J. Puckelwartz,
Fida Abuisneineh,
John P. Fahrenbach,
Yuan Zhang,
Heather MacLeod,
Lisa Dellefave,
Peter Pytel,
Sara Selig,
Christine M. Labno

Published: December 14, 2010
https://doi.org/10.1371/journal.pone.0014342

Reader Comments (1)

Post a new comment on this article

0 Responses

10 Jul 2012
22:16 GMT
Most Recent

Publisher's Note: Update to Table 1. Posted by PLOS_ONE_Group on 10 Jul 2012 at 22:16 GMT

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Fibroblasts
Is the Subject Area "Fibroblasts" applicable to this article?

Thanks for your feedback.
Heart
Is the Subject Area "Heart" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Lamins
Is the Subject Area "Lamins" applicable to this article?

Thanks for your feedback.
Mutation
Is the Subject Area "Mutation" applicable to this article?

Thanks for your feedback.
Microarrays
Is the Subject Area "Microarrays" applicable to this article?

Thanks for your feedback.
Nuclear membrane
Is the Subject Area "Nuclear membrane" applicable to this article?

Thanks for your feedback.
Chromatin
Is the Subject Area "Chromatin" applicable to this article?

Thanks for your feedback.