Genetic and Chemical Evaluation of Trypanosoma brucei Oleate Desaturase as a Candidate Drug Target

Andrés Alloatti; Shreedhara Gupta; Melisa Gualdrón-López; Mariana Igoillo-Esteve; Paul A. Nguewa; Gladys Deumer; Pierre Wallemacq; Silvia G. Altabe; Paul A. M. Michels; Antonio D. Uttaro

doi:10.1371/journal.pone.0014239

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Peer-reviewed

Research Article

Genetic and Chemical Evaluation of Trypanosoma brucei Oleate Desaturase as a Candidate Drug Target

Andrés Alloatti ,

Contributed equally to this work with: Andrés Alloatti, Shreedhara Gupta

Affiliation Facultad de Ciencias Bioquímicas y Farmacéuticas, Instituto de Biología Molecular y Celular de Rosario, CONICET, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina
⨯
Shreedhara Gupta ,

Contributed equally to this work with: Andrés Alloatti, Shreedhara Gupta

Affiliation Research Unit for Tropical Diseases, Laboratory of Biochemistry and de Duve Institute, Université catholique de Louvain, Brussels, Belgium
⨯
Melisa Gualdrón-López,

Affiliation Research Unit for Tropical Diseases, Laboratory of Biochemistry and de Duve Institute, Université catholique de Louvain, Brussels, Belgium
⨯
Mariana Igoillo-Esteve,

Affiliation Research Unit for Tropical Diseases, Laboratory of Biochemistry and de Duve Institute, Université catholique de Louvain, Brussels, Belgium
⨯
Paul A. Nguewa,

Affiliation Research Unit for Tropical Diseases, Laboratory of Biochemistry and de Duve Institute, Université catholique de Louvain, Brussels, Belgium
⨯
Gladys Deumer,

Affiliation Department of Clinical Chemistry, Cliniques universitaires Saint-Luc, LTAP, Université catholique de Louvain, Brussels, Belgium
⨯
Pierre Wallemacq,

Affiliation Department of Clinical Chemistry, Cliniques universitaires Saint-Luc, LTAP, Université catholique de Louvain, Brussels, Belgium
⨯
Silvia G. Altabe,

Affiliation Facultad de Ciencias Bioquímicas y Farmacéuticas, Instituto de Biología Molecular y Celular de Rosario, CONICET, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina
⨯
Paul A. M. Michels,

Affiliation Research Unit for Tropical Diseases, Laboratory of Biochemistry and de Duve Institute, Université catholique de Louvain, Brussels, Belgium
⨯
Antonio D. Uttaro

* E-mail: toniuttaro@yahoo.com.ar

Affiliation Facultad de Ciencias Bioquímicas y Farmacéuticas, Instituto de Biología Molecular y Celular de Rosario, CONICET, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina
⨯

Genetic and Chemical Evaluation of Trypanosoma brucei Oleate Desaturase as a Candidate Drug Target

Andrés Alloatti,
Shreedhara Gupta,
Melisa Gualdrón-López,
Mariana Igoillo-Esteve,
Paul A. Nguewa,
Gladys Deumer,
Pierre Wallemacq,
Silvia G. Altabe,
Paul A. M. Michels,
Antonio D. Uttaro

Published: December 6, 2010
https://doi.org/10.1371/journal.pone.0014239

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Trypanosoma
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Oleates
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Trypanosoma brucei gambiense
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Fatty acids
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