Combination Treatment with MEK and AKT Inhibitors Is More Effective than Each Drug Alone in Human Non-Small Cell Lung Cancer In Vitro and In Vivo

Jieru Meng; Bingbing Dai; Bingliang Fang; B. Nebiyou Bekele; William G. Bornmann; Duoli Sun; Zhenghong Peng; Roy S. Herbst; Vassiliki Papadimitrakopoulou; John D. Minna; Michael Peyton; Jack A. Roth

doi:10.1371/journal.pone.0014124

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Open Access

Peer-reviewed

Research Article

Combination Treatment with MEK and AKT Inhibitors Is More Effective than Each Drug Alone in Human Non-Small Cell Lung Cancer In Vitro and In Vivo

Jieru Meng ,

* E-mail: jmeng@mdanderson.org

Affiliation Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Bingbing Dai,

Affiliation Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Bingliang Fang,

Affiliation Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
B. Nebiyou Bekele,

Affiliation Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
William G. Bornmann,

Affiliation Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Duoli Sun,

Affiliation Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Zhenghong Peng,

Affiliation Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Roy S. Herbst,

Affiliation Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Vassiliki Papadimitrakopoulou,

Affiliation Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
John D. Minna,

Affiliation Hamon Center for Therapeutic Oncology Research, and Simmons Cancer Center, The University of Texas Southwestern Medical Center at Dallas, Texas, United States of America
⨯
Michael Peyton,

Affiliation Hamon Center for Therapeutic Oncology Research, and Simmons Cancer Center, The University of Texas Southwestern Medical Center at Dallas, Texas, United States of America
⨯
Jack A. Roth

Affiliation Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯

Combination Treatment with MEK and AKT Inhibitors Is More Effective than Each Drug Alone in Human Non-Small Cell Lung Cancer In Vitro and In Vivo

Jieru Meng,
Bingbing Dai,
Bingliang Fang,
B. Nebiyou Bekele,
William G. Bornmann,
Duoli Sun,
Zhenghong Peng,
Roy S. Herbst,
Vassiliki Papadimitrakopoulou,
John D. Minna

Published: November 29, 2010
https://doi.org/10.1371/journal.pone.0014124

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