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Open Access

Peer-reviewed

Research Article

Downregulation of uPAR and Cathepsin B Induces Apoptosis via Regulation of Bcl-2 and Bax and Inhibition of the PI3K/Akt Pathway in Gliomas

Ramarao Malla,

Affiliation Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
⨯
Sreelatha Gopinath,

Affiliation Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
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Kiranmai Alapati,

Affiliation Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
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Christopher S. Gondi,

Affiliation Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
⨯
Meena Gujrati,

Affiliation Department of Pathology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
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Dzung H. Dinh,

Affiliation Department of Neurosurgery, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
⨯
Sanjeeva Mohanam,

Affiliation Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
⨯
Jasti S. Rao

* E-mail: jsrao@uic.edu

Affiliations Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America, Department of Neurosurgery, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
⨯

Downregulation of uPAR and Cathepsin B Induces Apoptosis via Regulation of Bcl-2 and Bax and Inhibition of the PI3K/Akt Pathway in Gliomas

Ramarao Malla,
Sreelatha Gopinath,
Kiranmai Alapati,
Christopher S. Gondi,
Meena Gujrati,
Dzung H. Dinh,
Sanjeeva Mohanam,
Jasti S. Rao

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Published: October 29, 2010
https://doi.org/10.1371/journal.pone.0013731

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Apoptosis
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Mitochondria
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Transfection
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Small interfering RNA
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Glioma cells
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Immunoprecipitation
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Mitochondrial membrane
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Membrane potential
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