Synphilin-1 Enhances α-Synuclein Aggregation in Yeast and Contributes to Cellular Stress and Cell Death in a Sir2-Dependent Manner

• Sabrina Büttner ,

  Contributed equally to this work with: Sabrina Büttner, Charlotte Delay, Vanessa Franssens

  Affiliation Institute of Molecular Biosciences, University of Graz, Graz, Austria

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• Charlotte Delay ,

  Contributed equally to this work with: Sabrina Büttner, Charlotte Delay, Vanessa Franssens

  Affiliations Functional Biology, Katholieke Universiteit Leuven, Heverlee, Belgium, Alzheimer & Tauopathies, Inserm U837, Lille, France, Jean-Pierre Aubert Research Centre, Université Lille Nord de France, Lille, France, Faculté de Médecine-Pole Recherche, Université du Droit et de la Santé de Lille, Lille, France, Centre Hospitalier Universitaire, Lille, France

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• Vanessa Franssens ,

  Contributed equally to this work with: Sabrina Büttner, Charlotte Delay, Vanessa Franssens

  Affiliation Functional Biology, Katholieke Universiteit Leuven, Heverlee, Belgium

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• Tine Bammens,

  Affiliation Functional Biology, Katholieke Universiteit Leuven, Heverlee, Belgium

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• Doris Ruli,

  Affiliation Institute of Molecular Biosciences, University of Graz, Graz, Austria

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• Sandra Zaunschirm,

  Affiliation Institute of Molecular Biosciences, University of Graz, Graz, Austria

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• Rita Machado de Oliveira,

  Affiliations Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisboa, Portugal, Instituto de Fisiologia, Universidade de Lisboa, Lisboa, Portugal

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• Tiago Fleming Outeiro,

  Affiliations Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisboa, Portugal, Instituto de Fisiologia, Universidade de Lisboa, Lisboa, Portugal

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• Frank Madeo,

  Affiliation Institute of Molecular Biosciences, University of Graz, Graz, Austria

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• Luc Buée,

  Affiliations Alzheimer & Tauopathies, Inserm U837, Lille, France, Jean-Pierre Aubert Research Centre, Université Lille Nord de France, Lille, France, Faculté de Médecine-Pole Recherche, Université du Droit et de la Santé de Lille, Lille, France, Centre Hospitalier Universitaire, Lille, France

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• Marie-Christine Galas,

  Affiliations Alzheimer & Tauopathies, Inserm U837, Lille, France, Jean-Pierre Aubert Research Centre, Université Lille Nord de France, Lille, France, Faculté de Médecine-Pole Recherche, Université du Droit et de la Santé de Lille, Lille, France, Centre Hospitalier Universitaire, Lille, France

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• Joris Winderickx

  * E-mail: joris.winderickx@bio.kuleuven.be

  Affiliation Functional Biology, Katholieke Universiteit Leuven, Heverlee, Belgium

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