Whole Blood Transcriptomics in Cardiac Surgery Identifies a Gene Regulatory Network Connecting Ischemia Reperfusion with Systemic Inflammation

Orfeas Liangos; Sophie Domhan; Christian Schwager; Martin Zeier; Peter E. Huber; Francesco Addabbo; Michael S. Goligorsky; Lynn Hlatky; Bertrand L. Jaber; Amir Abdollahi

doi:10.1371/journal.pone.0013658

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Peer-reviewed

Research Article

Whole Blood Transcriptomics in Cardiac Surgery Identifies a Gene Regulatory Network Connecting Ischemia Reperfusion with Systemic Inflammation

Orfeas Liangos ,

* E-mail: liangos_o@hotmail.com (OL); amir.abdollahi@tufts.edu (AA)

Affiliation The Kidney and Dialysis Research Laboratory, Division of Nephrology, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts, United States of America
⨯
Sophie Domhan,

Affiliations Center of Cancer Systems Biology, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Department of Nephrology, University Medical School and German Cancer Research Center, Heidelberg, Germany
⨯
Christian Schwager,

Affiliation Department of Radiation Oncology, University Medical School and German Cancer Research Center, Heidelberg, Germany
⨯
Martin Zeier,

Affiliation Department of Nephrology, University Medical School and German Cancer Research Center, Heidelberg, Germany
⨯
Peter E. Huber,

Affiliation Department of Radiation Oncology, University Medical School and German Cancer Research Center, Heidelberg, Germany
⨯
Francesco Addabbo,

Affiliation Division of Nephrology, New York Medical College, Valhalla, New York, United States of America
⨯
Michael S. Goligorsky,

Affiliation Division of Nephrology, New York Medical College, Valhalla, New York, United States of America
⨯
Lynn Hlatky,

Affiliation Center of Cancer Systems Biology, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts, United States of America
⨯
Bertrand L. Jaber,

Affiliation The Kidney and Dialysis Research Laboratory, Division of Nephrology, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts, United States of America
⨯
Amir Abdollahi

* E-mail: liangos_o@hotmail.com (OL); amir.abdollahi@tufts.edu (AA)

Affiliations Center of Cancer Systems Biology, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Department of Radiation Oncology, University Medical School and German Cancer Research Center, Heidelberg, Germany
⨯

Whole Blood Transcriptomics in Cardiac Surgery Identifies a Gene Regulatory Network Connecting Ischemia Reperfusion with Systemic Inflammation

Orfeas Liangos,
Sophie Domhan,
Christian Schwager,
Martin Zeier,
Peter E. Huber,
Francesco Addabbo,
Michael S. Goligorsky,
Lynn Hlatky,
Bertrand L. Jaber,
Amir Abdollahi

Published: October 27, 2010
https://doi.org/10.1371/journal.pone.0013658

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Inflammation
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Blood
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Cardiopulmonary bypass
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Transcriptome analysis
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Cardiac surgery
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Microarrays
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White blood cells
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