Alkylation of the Tumor Suppressor PTEN Activates Akt and β-Catenin Signaling: A Mechanism Linking Inflammation and Oxidative Stress with Cancer

• Tracy M. Covey,

  Current address: Program in Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore

  Affiliation Department of Medicinal Chemistry, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America

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• Kornelia Edes,

  Affiliation Department of Medicinal Chemistry, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America

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• Gary S. Coombs,

  Current address: Program in Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore

  Affiliation Department of Medicinal Chemistry, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America

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• David M. Virshup,

  Current address: Program in Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore

  Affiliation Department of Medicinal Chemistry, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America

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• Frank A. Fitzpatrick

  * E-mail: FFitzpatrick@kcumb.edu

  Current address: Kansas City University of Medicine and Biosciences, Kansas City, Missouri, United States of America

  Affiliation Department of Medicinal Chemistry, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America

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