The Lack of ADAM17 Activity during Embryonic Development Causes Hemorrhage and Impairs Vessel Formation

Matthias Canault; Kaan Certel; Daphne Schatzberg; Denisa D. Wagner; Richard O. Hynes

doi:10.1371/journal.pone.0013433

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Research Article

The Lack of ADAM17 Activity during Embryonic Development Causes Hemorrhage and Impairs Vessel Formation

Matthias Canault ,

Contributed equally to this work with: Matthias Canault, Kaan Certel

Affiliations Immune Disease Institute, Boston, Massachusetts, United States of America, Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Kaan Certel ,

Contributed equally to this work with: Matthias Canault, Kaan Certel

Affiliations Howard Hughes Medical Institute, Chevy Chase, Massachusetts, United States of America, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Daphne Schatzberg,

Affiliations Immune Disease Institute, Boston, Massachusetts, United States of America, Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, Massachusetts, United States of America
⨯
Denisa D. Wagner ,

* E-mail: wagner@idi.harvard.edu (DDW); rohynes@mit.edu (ROH)

¶These authors also contributed equally to this work.

Affiliations Immune Disease Institute, Boston, Massachusetts, United States of America, Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Richard O. Hynes

* E-mail: wagner@idi.harvard.edu (DDW); rohynes@mit.edu (ROH)

¶These authors also contributed equally to this work.

Affiliations Howard Hughes Medical Institute, Chevy Chase, Massachusetts, United States of America, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯

The Lack of ADAM17 Activity during Embryonic Development Causes Hemorrhage and Impairs Vessel Formation

Matthias Canault,
Kaan Certel,
Daphne Schatzberg,
Denisa D. Wagner,
Richard O. Hynes

Published: October 15, 2010
https://doi.org/10.1371/journal.pone.0013433

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Embryos
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Hemorrhage
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Angiogenesis
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