Nitrate Respiration Protects Hypoxic Mycobacterium tuberculosis Against Acid- and Reactive Nitrogen Species Stresses

Mai Ping Tan; Patricia Sequeira; Wen Wei Lin; Wai Yee Phong; Penelope Cliff; Seow Hwee Ng; Boon Heng Lee; Luis Camacho; Dirk Schnappinger; Sabine Ehrt; Thomas Dick; Kevin Pethe; Sylvie Alonso

doi:10.1371/journal.pone.0013356

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Open Access

Peer-reviewed

Research Article

Nitrate Respiration Protects Hypoxic Mycobacterium tuberculosis Against Acid- and Reactive Nitrogen Species Stresses

Mai Ping Tan,

Current address: Department of Infection, Immunity and Biochemistry, Cardiff University, Cardiff, Wales

Affiliation Novartis Institute for Tropical Diseases, Singapore, Singapore
⨯
Patricia Sequeira,

Affiliation Novartis Institute for Tropical Diseases, Singapore, Singapore
⨯
Wen Wei Lin,

Affiliation Immunology Programme, Department of Microbiology, National University of Singapore, Singapore, Singapore
⨯
Wai Yee Phong,

Affiliation Novartis Institute for Tropical Diseases, Singapore, Singapore
⨯
Penelope Cliff,

Affiliation Novartis Institute for Tropical Diseases, Singapore, Singapore
⨯
Seow Hwee Ng,

Affiliation Novartis Institute for Tropical Diseases, Singapore, Singapore
⨯
Boon Heng Lee,

Affiliation Novartis Institute for Tropical Diseases, Singapore, Singapore
⨯
Luis Camacho,

Affiliation Novartis Institute for Tropical Diseases, Singapore, Singapore
⨯
Dirk Schnappinger,

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America
⨯
Sabine Ehrt,

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America
⨯
Thomas Dick,

Affiliation Novartis Institute for Tropical Diseases, Singapore, Singapore
⨯
Kevin Pethe ,

* E-mail: kevin.pethe@novartis.com (KP); micas@nus.edu.sg (SA)

Affiliation Novartis Institute for Tropical Diseases, Singapore, Singapore
⨯
Sylvie Alonso

* E-mail: kevin.pethe@novartis.com (KP); micas@nus.edu.sg (SA)

Affiliation Immunology Programme, Department of Microbiology, National University of Singapore, Singapore, Singapore
⨯

Nitrate Respiration Protects Hypoxic Mycobacterium tuberculosis Against Acid- and Reactive Nitrogen Species Stresses

Mai Ping Tan,
Patricia Sequeira,
Wen Wei Lin,
Wai Yee Phong,
Penelope Cliff,
Seow Hwee Ng,
Boon Heng Lee,
Luis Camacho,
Dirk Schnappinger,
Sabine Ehrt

Published: October 26, 2010
https://doi.org/10.1371/journal.pone.0013356

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