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Open Access

Peer-reviewed

Research Article

The Bile Acid Sensor FXR Protects against Dyslipidemia and Aortic Plaques Development Induced by the HIV Protease Inhibitor Ritonavir in Mice

Andrea Mencarelli,

Affiliation Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Facoltà di Medicina e Chirurgia, Perugia, Italy
⨯
Sabrina Cipriani,

Affiliation Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Facoltà di Medicina e Chirurgia, Perugia, Italy
⨯
Barbara Renga,

Affiliation Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Facoltà di Medicina e Chirurgia, Perugia, Italy
⨯
Daniela Francisci,

Affiliation Dipartimento di Medicina Sperimentale e Scienze Biochimiche, University of Perugia, Facoltà di Medicina e Chirurgia, Perugia, Italy
⨯
Giuseppe Palladino,

Affiliation Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Facoltà di Medicina e Chirurgia, Perugia, Italy
⨯
Eleonora Distrutti,

Affiliation Azienda Ospedaliera di Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy
⨯
Franco Baldelli,

Affiliation Dipartimento di Medicina Sperimentale e Scienze Biochimiche, University of Perugia, Facoltà di Medicina e Chirurgia, Perugia, Italy
⨯
Stefano Fiorucci

* E-mail: fiorucci@unipg.it

Affiliation Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Facoltà di Medicina e Chirurgia, Perugia, Italy
⨯

The Bile Acid Sensor FXR Protects against Dyslipidemia and Aortic Plaques Development Induced by the HIV Protease Inhibitor Ritonavir in Mice

Andrea Mencarelli,
Sabrina Cipriani,
Barbara Renga,
Daniela Francisci,
Giuseppe Palladino,
Eleonora Distrutti,
Franco Baldelli,
Stefano Fiorucci

x

Published: October 8, 2010
https://doi.org/10.1371/journal.pone.0013238

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Cholesterol
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Macrophages
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Fatty liver
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Dyslipidemia
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HIV
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Gene expression
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Atherosclerosis
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Protease inhibitor therapy
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