1H-NMR-Based Metabolomic Profiling of CSF in Early Amyotrophic Lateral Sclerosis

Hélène Blasco; Philippe Corcia; Caroline Moreau; Ségolène Veau; Clémentine Fournier; Patrick Vourc'h; Patrick Emond; Paul Gordon; Pierre-François Pradat; Julien Praline; David Devos; Lydie Nadal-Desbarats; Christian R. Andres

doi:10.1371/journal.pone.0013223

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Open Access

Peer-reviewed

Research Article

¹H-NMR-Based Metabolomic Profiling of CSF in Early Amyotrophic Lateral Sclerosis

Hélène Blasco ,

* E-mail: helene.blasco@univ-tours.fr

Affiliations Inserm U930, CNRS 2448, Tours, France, Université François-Rabelais, Tours, France, CHRU de Tours, Laboratoire de Biochimie et Biologie Moléculaire, Tours, France
⨯
Philippe Corcia,

Affiliations Inserm U930, CNRS 2448, Tours, France, Université François-Rabelais, Tours, France, CHRU de Tours, Service de Neurologie, Tours, France
⨯
Caroline Moreau,

Affiliation CHRU de Lille, Service de Neurologie, Lille, France
⨯
Ségolène Veau,

Affiliation CHRU de Tours, Laboratoire de Biochimie et Biologie Moléculaire, Tours, France
⨯
Clémentine Fournier,

Affiliation CHRU de Tours, Laboratoire de Biochimie et Biologie Moléculaire, Tours, France
⨯
Patrick Vourc'h,

Affiliations Inserm U930, CNRS 2448, Tours, France, Université François-Rabelais, Tours, France, CHRU de Tours, Laboratoire de Biochimie et Biologie Moléculaire, Tours, France, Laboratoire de RMN - PPF “Analyses des Systèmes Biologiques”, Université François-Rabelais, Tours, France
⨯
Patrick Emond,

Affiliations Inserm U930, CNRS 2448, Tours, France, Université François-Rabelais, Tours, France, CHRU de Tours, Laboratoire de Biochimie et Biologie Moléculaire, Tours, France, Laboratoire de RMN - PPF “Analyses des Systèmes Biologiques”, Université François-Rabelais, Tours, France
⨯
Paul Gordon,

Affiliation Northern Navajo Medical Center, Shiprock, New Mexico, United States of America
⨯
Pierre-François Pradat,

Affiliation APHP, Fédération des Maladies du Système Nerveux, Centre Référent Maladie Rare SLA, Hôpital de la Pitié-Salpétriere, Paris, France
⨯
Julien Praline,

Affiliations Inserm U930, CNRS 2448, Tours, France, Université François-Rabelais, Tours, France, CHRU de Tours, Service de Neurologie, Tours, France
⨯
David Devos,

Affiliation CHRU de Lille, Service de Neurologie, Lille, France
⨯
Lydie Nadal-Desbarats,

Affiliations Inserm U930, CNRS 2448, Tours, France, Université François-Rabelais, Tours, France, Laboratoire de RMN - PPF “Analyses des Systèmes Biologiques”, Université François-Rabelais, Tours, France
⨯
Christian R. Andres

Affiliations Inserm U930, CNRS 2448, Tours, France, Université François-Rabelais, Tours, France, CHRU de Tours, Laboratoire de Biochimie et Biologie Moléculaire, Tours, France
⨯

¹H-NMR-Based Metabolomic Profiling of CSF in Early Amyotrophic Lateral Sclerosis

Hélène Blasco,
Philippe Corcia,
Caroline Moreau,
Ségolène Veau,
Clémentine Fournier,
Patrick Vourc'h,
Patrick Emond,
Paul Gordon,
Pierre-François Pradat,
Julien Praline

Published: October 8, 2010
https://doi.org/10.1371/journal.pone.0013223

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Cerebrospinal fluid
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Metabolites
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NMR spectroscopy
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Amyotrophic lateral sclerosis
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