Natural Killer Cell Tolerance Persists Despite Significant Reduction of Self MHC Class I on Normal Target Cells in Mice

Petter Brodin; Tadepally Lakshmikanth; Ramit Mehr; Maria H. Johansson; Adil Doganay Duru; Adnane Achour; Mali Salmon-Divon; Klas Kärre; Petter Höglund; Sofia Johansson

doi:10.1371/journal.pone.0013174

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Peer-reviewed

Research Article

Natural Killer Cell Tolerance Persists Despite Significant Reduction of Self MHC Class I on Normal Target Cells in Mice

Petter Brodin ,

Contributed equally to this work with: Petter Brodin, Tadepally Lakshmikanth

Affiliation Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
⨯
Tadepally Lakshmikanth ,

Contributed equally to this work with: Petter Brodin, Tadepally Lakshmikanth

Affiliation Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
⨯
Ramit Mehr,

Affiliation The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
⨯
Maria H. Johansson,

Affiliation Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
⨯
Adil Doganay Duru,

Affiliation Department of Medicine, Center for Infectious Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Sweden
⨯
Adnane Achour,

Affiliation Department of Medicine, Center for Infectious Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Sweden
⨯
Mali Salmon-Divon,

Affiliations The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel, European Molecular Biology Laboratory (EMBL) European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
⨯
Klas Kärre,

Affiliation Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
⨯
Petter Höglund,

Affiliation Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
⨯
Sofia Johansson

* E-mail: sofj@kth.se

Affiliation Department of Applied Physics, Experimental Biomolecular Physics, Royal Institute of Technology, AlbaNova University Center, Stockholm, Sweden
⨯

Natural Killer Cell Tolerance Persists Despite Significant Reduction of Self MHC Class I on Normal Target Cells in Mice

Petter Brodin,
Tadepally Lakshmikanth,
Ramit Mehr,
Maria H. Johansson,
Adil Doganay Duru,
Adnane Achour,
Mali Salmon-Divon,
Klas Kärre,
Petter Höglund,
Sofia Johansson

Published: October 4, 2010
https://doi.org/10.1371/journal.pone.0013174

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NK cells
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MHC class I genes
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Homozygosity
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Killer activated and killer inhibitor receptors
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