Equitoxic Doses of 5-Azacytidine and 5-Aza-2′Deoxycytidine Induce Diverse Immediate and Overlapping Heritable Changes in the Transcriptome

Xiangning Qiu; Christoffer Hother; Ulrik M. Ralfkiær; Alexandra Søgaard; Qianjin Lu; Christopher T. Workman; Gangning Liang; Peter A. Jones; Kirsten Grønbæk

doi:10.1371/journal.pone.0012994

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Peer-reviewed

Research Article

Equitoxic Doses of 5-Azacytidine and 5-Aza-2′Deoxycytidine Induce Diverse Immediate and Overlapping Heritable Changes in the Transcriptome

Xiangning Qiu ,

Contributed equally to this work with: Xiangning Qiu, Christoffer Hother

Affiliations Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California, United States of America, Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
⨯
Christoffer Hother ,

Contributed equally to this work with: Xiangning Qiu, Christoffer Hother

Affiliation Department of Hematology, Rigshospitalet, Copenhagen, Denmark
⨯
Ulrik M. Ralfkiær,

Affiliation Department of Hematology, Rigshospitalet, Copenhagen, Denmark
⨯
Alexandra Søgaard,

Affiliation Department of Hematology, Rigshospitalet, Copenhagen, Denmark
⨯
Qianjin Lu,

Affiliation Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
⨯
Christopher T. Workman,

Affiliation Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark
⨯
Gangning Liang,

Affiliation Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California, United States of America
⨯
Peter A. Jones,

Affiliation Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California, United States of America
⨯
Kirsten Grønbæk

* E-mail: kirsten.groenbaek@rh.regionh.dk

Affiliation Department of Hematology, Rigshospitalet, Copenhagen, Denmark
⨯

Equitoxic Doses of 5-Azacytidine and 5-Aza-2′Deoxycytidine Induce Diverse Immediate and Overlapping Heritable Changes in the Transcriptome

Xiangning Qiu,
Christoffer Hother,
Ulrik M. Ralfkiær,
Alexandra Søgaard,
Qianjin Lu,
Christopher T. Workman,
Gangning Liang,
Peter A. Jones,
Kirsten Grønbæk

Published: September 29, 2010
https://doi.org/10.1371/journal.pone.0012994

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