Crystal Structure of a Complex between Amino and Carboxy Terminal Fragments of mDia1: Insights into Autoinhibition of Diaphanous-Related Formins

Open Access

Peer-reviewed

Research Article

Azin Nezami,

Current address: Vertex Pharmaceuticals, Cambridge, Massachusetts, United States of America

Affiliations Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
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Florence Poy,

Current address: Constellation Pharmaceuticals, Cambridge, Massachusetts, United States of America

Affiliation Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
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Angela Toms,

Affiliations Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
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Wei Zheng,

Affiliations Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
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Michael J. Eck

* E-mail: eck@red.dfci.harvard.edu

Affiliations Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
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Crystal structure
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Crystallization
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Actins
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Actin filaments
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Dimerization
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Nucleation
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Nuclear actin filaments
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Protein structure
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