Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

Open Access

Peer-reviewed

Research Article

Wen-I Wu,

Affiliation Department of Structural Biology, Array BioPharma Inc., Boulder, Colorado, United States of America
⨯
Walter C. Voegtli,

Affiliation Department of Structural Biology, Array BioPharma Inc., Boulder, Colorado, United States of America
⨯
Hillary L. Sturgis,

Affiliation Department of Structural Biology, Array BioPharma Inc., Boulder, Colorado, United States of America
⨯
Faith P. Dizon,

Affiliation Department of Structural Biology, Array BioPharma Inc., Boulder, Colorado, United States of America
⨯
Guy P. A. Vigers,

Affiliation Department of Structural Biology, Array BioPharma Inc., Boulder, Colorado, United States of America
⨯
Barbara J. Brandhuber

* E-mail: bbrandhuber@arraybiopharma.com

Affiliation Department of Structural Biology, Array BioPharma Inc., Boulder, Colorado, United States of America
⨯

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Cell membranes
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Crystal structure
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Isozymes
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Crystals
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Cancers and neoplasms
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Enzyme structure
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Allosteric regulation
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Cancer treatment
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