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Open Access

Peer-reviewed

Research Article

Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype

Robert W. Tilghman,

Affiliation Department of Microbiology and Cancer Center, School of Medicine, University of Virginia, Charlottesville, Virginia, United States of America
⨯
Catharine R. Cowan,

Affiliation Department of Microbiology and Cancer Center, School of Medicine, University of Virginia, Charlottesville, Virginia, United States of America
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Justin D. Mih,

Affiliation Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, Massachusetts, United States of America
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Yulia Koryakina,

Affiliation Department of Microbiology and Cancer Center, School of Medicine, University of Virginia, Charlottesville, Virginia, United States of America
⨯
Daniel Gioeli,

Affiliation Department of Microbiology and Cancer Center, School of Medicine, University of Virginia, Charlottesville, Virginia, United States of America
⨯
Jill K. Slack-Davis,

Affiliation Department of Microbiology and Cancer Center, School of Medicine, University of Virginia, Charlottesville, Virginia, United States of America
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Brett R. Blackman,

Affiliation Department of Biomedical Engineering, School of Medicine, University of Virginia, Charlottesville, Virginia, United States of America
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Daniel J. Tschumperlin,

Affiliation Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
J. Thomas Parsons

* E-mail: jtp@virginia.edu

Affiliation Department of Microbiology and Cancer Center, School of Medicine, University of Virginia, Charlottesville, Virginia, United States of America
⨯

Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype

Robert W. Tilghman,
Catharine R. Cowan,
Justin D. Mih,
Yulia Koryakina,
Daniel Gioeli,
Jill K. Slack-Davis,
Brett R. Blackman,
Daniel J. Tschumperlin,
J. Thomas Parsons

x

Published: September 23, 2010
https://doi.org/10.1371/journal.pone.0012905

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Lung and intrathoracic tumors
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Extracellular matrix
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Breast cancer
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Cancers and neoplasms
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Cell cycle and cell division
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Cell growth
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Cultured fibroblasts
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Soft tissues
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