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Open Access

Peer-reviewed

Research Article

siRNA-Based Targeting of Cyclin E Overexpression Inhibits Breast Cancer Cell Growth and Suppresses Tumor Development in Breast Cancer Mouse Model

Yulong Liang,

Affiliation The Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Hong Gao,

Affiliation The Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Shiaw-Yih Lin,

Affiliation Department of Systems Biology, M.D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
John A. Goss,

Affiliation The Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Francis C. Brunicardi,

Affiliation The Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Kaiyi Li

* E-mail: kli@bcm.tmc.edu

Affiliation The Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, United States of America
⨯

siRNA-Based Targeting of Cyclin E Overexpression Inhibits Breast Cancer Cell Growth and Suppresses Tumor Development in Breast Cancer Mouse Model

Yulong Liang,
Hong Gao,
Shiaw-Yih Lin,
John A. Goss,
Francis C. Brunicardi,
Kaiyi Li

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Published: September 20, 2010
https://doi.org/10.1371/journal.pone.0012860

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Small interfering RNA
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Breast cancer
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Cancer treatment
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Apoptosis
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Transfection
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Cyclins
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Mouse models
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Genetically modified animals
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