Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation

• Amy V. Pointon,

  Current address: Department of Molecular Toxicology, AstraZeneca, Macclesfield, United Kingdom

  Affiliation Medical Research Council Toxicology Unit, Systems Toxicology Group, Leicester, United Kingdom

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• Tracy M. Walker,

  Affiliation GlaxoSmithKline PLC, Ware, United Kingdom

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• Kate M. Phillips,

  Affiliation Medical Research Council Toxicology Unit, Systems Toxicology Group, Leicester, United Kingdom

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• Jinli Luo,

  Affiliation Medical Research Council Toxicology Unit, Systems Toxicology Group, Leicester, United Kingdom

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• Joan Riley,

  Affiliation Medical Research Council Toxicology Unit, Systems Toxicology Group, Leicester, United Kingdom

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• Shu-Dong Zhang,

  Current address: Centre for Cancer Research and Cell Biology (CCRCB), Queen's University, Belfast, United Kingdom

  Affiliation Medical Research Council Toxicology Unit, Systems Toxicology Group, Leicester, United Kingdom

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• Joel D. Parry,

  Affiliation GlaxoSmithKline PLC, Ware, United Kingdom

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• Jonathan J. Lyon,

  Affiliation GlaxoSmithKline PLC, Ware, United Kingdom

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• Emma L. Marczylo,

  Affiliation Medical Research Council Toxicology Unit, Systems Toxicology Group, Leicester, United Kingdom

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• Timothy W. Gant

  * E-mail: twg1@le.ac.uk

  Affiliation Medical Research Council Toxicology Unit, Systems Toxicology Group, Leicester, United Kingdom

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