Akt Deficiency Attenuates Muscle Size and Function but Not the Response to ActRIIB Inhibition

Marcus D. Goncalves; Emidio E. Pistilli; Anthony Balduzzi; Morris J. Birnbaum; Jennifer Lachey; Tejvir S. Khurana; Rexford S. Ahima

doi:10.1371/journal.pone.0012707

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Research Article

Akt Deficiency Attenuates Muscle Size and Function but Not the Response to ActRIIB Inhibition

Marcus D. Goncalves,

Affiliations Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Emidio E. Pistilli,

Affiliation Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Anthony Balduzzi,

Affiliation Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Morris J. Birnbaum,

Affiliations Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Jennifer Lachey,

Affiliation Acceleron Pharma, Cambridge, Massachusetts, United States of America
⨯
Tejvir S. Khurana,

Affiliation Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Rexford S. Ahima

* E-mail: ahima@mail.med.upenn.edu

Affiliations Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯

Akt Deficiency Attenuates Muscle Size and Function but Not the Response to ActRIIB Inhibition

Marcus D. Goncalves,
Emidio E. Pistilli,
Anthony Balduzzi,
Morris J. Birnbaum,
Jennifer Lachey,
Tejvir S. Khurana,
Rexford S. Ahima

Published: September 15, 2010
https://doi.org/10.1371/journal.pone.0012707

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