Regulation of Heparin-Binding EGF-Like Growth Factor by miR-212 and Acquired Cetuximab-Resistance in Head and Neck Squamous Cell Carcinoma

Hiromitsu Hatakeyama; Haixia Cheng; Pamela Wirth; Ashley Counsell; Samuel R. Marcrom; Carey Burton Wood; Paula R. Pohlmann; Jill Gilbert; Barbara Murphy; Wendell G. Yarbrough; Deric L. Wheeler; Paul M. Harari; Yan Guo; Yu Shyr; Robbert J. Slebos; Christine H. Chung

doi:10.1371/journal.pone.0012702

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Peer-reviewed

Research Article

Regulation of Heparin-Binding EGF-Like Growth Factor by miR-212 and Acquired Cetuximab-Resistance in Head and Neck Squamous Cell Carcinoma

Hiromitsu Hatakeyama,

Affiliation Division of Hematology/Oncology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Haixia Cheng,

Affiliation Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Pamela Wirth,

Affiliation Division of Hematology/Oncology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Ashley Counsell,

Affiliation Division of Hematology/Oncology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Samuel R. Marcrom,

Affiliation Division of Hematology/Oncology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Carey Burton Wood,

Affiliation Division of Hematology/Oncology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Paula R. Pohlmann,

Affiliation Division of Hematology/Oncology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Jill Gilbert,

Affiliation Division of Hematology/Oncology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Barbara Murphy,

Affiliation Division of Hematology/Oncology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Wendell G. Yarbrough,

Affiliations Department of Otolaryngology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Deric L. Wheeler,

Affiliation Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Paul M. Harari,

Affiliation Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Yan Guo,

Affiliations Division of Hematology/Oncology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Biostatistics, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Yu Shyr,

Affiliation Department of Biostatistics, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Robbert J. Slebos,

Affiliation Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
[ ... ],
Christine H. Chung

* E-mail: cchung11@jhmi.edu

Affiliation Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
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Regulation of Heparin-Binding EGF-Like Growth Factor by miR-212 and Acquired Cetuximab-Resistance in Head and Neck Squamous Cell Carcinoma

Hiromitsu Hatakeyama,
Haixia Cheng,
Pamela Wirth,
Ashley Counsell,
Samuel R. Marcrom,
Carey Burton Wood,
Paula R. Pohlmann,
Jill Gilbert,
Barbara Murphy,
Wendell G. Yarbrough

Published: September 13, 2010
https://doi.org/10.1371/journal.pone.0012702

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Head and neck squamous cell carcinoma
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