Integrated Ligand-Receptor Bioinformatic and In Vitro Functional Analysis Identifies Active TGFA/EGFR Signaling Loop in Papillary Thyroid Carcinomas

Debora Degl'Innocenti; Chiara Alberti; Giancarlo Castellano; Angela Greco; Claudia Miranda; Marco A. Pierotti; Ettore Seregni; Maria Grazia Borrello; Silvana Canevari; Antonella Tomassetti

doi:10.1371/journal.pone.0012701

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Peer-reviewed

Research Article

Integrated Ligand-Receptor Bioinformatic and In Vitro Functional Analysis Identifies Active TGFA/EGFR Signaling Loop in Papillary Thyroid Carcinomas

Debora Degl'Innocenti,

Affiliation Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Chiara Alberti,

Affiliation Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Giancarlo Castellano,

Affiliation Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Angela Greco,

Affiliation Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Claudia Miranda,

Affiliation Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Marco A. Pierotti,

Affiliation Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Ettore Seregni,

Affiliation Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Maria Grazia Borrello ,

* E-mail: mariagrazia.borrello@istitutotumori.mi.it (MGB); silvana.canevari@istitutotumori.mi.it (SC)

Affiliation Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Silvana Canevari ,

* E-mail: mariagrazia.borrello@istitutotumori.mi.it (MGB); silvana.canevari@istitutotumori.mi.it (SC)

Affiliation Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Antonella Tomassetti

Affiliation Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯

Integrated Ligand-Receptor Bioinformatic and In Vitro Functional Analysis Identifies Active TGFA/EGFR Signaling Loop in Papillary Thyroid Carcinomas

Debora Degl'Innocenti,
Chiara Alberti,
Giancarlo Castellano,
Angela Greco,
Claudia Miranda,
Marco A. Pierotti,
Ettore Seregni,
Maria Grazia Borrello,
Silvana Canevari,
Antonella Tomassetti

Published: September 22, 2010
https://doi.org/10.1371/journal.pone.0012701

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Thyroid carcinoma
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TGF-beta signaling cascade
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Thyroid
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Gene expression
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Reverse transcriptase-polymerase chain reaction
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Phosphorylation
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Bioinformatics
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EGFR signaling
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