A Whole-Genome SNP Association Study of NCI60 Cell Line Panel Indicates a Role of Ca2+ Signaling in Selenium Resistance

Sevtap Savas; Laurent Briollais; Irada Ibrahim-zada; Hamdi Jarjanazi; Yun Hee Choi; Mireia Musquera; Neil Fleshner; Vasundara Venkateswaran; Hilmi Ozcelik

doi:10.1371/journal.pone.0012601

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Open Access

Peer-reviewed

Research Article

A Whole-Genome SNP Association Study of NCI60 Cell Line Panel Indicates a Role of Ca²⁺ Signaling in Selenium Resistance

Sevtap Savas,

Affiliations Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
⨯
Laurent Briollais,

Affiliation Prosserman Centre for Health Research, Mount Sinai Hospital, Toronto, Ontario, Canada
⨯
Irada Ibrahim-zada,

Affiliations Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
⨯
Hamdi Jarjanazi,

Affiliations Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
⨯
Yun Hee Choi,

Affiliation Prosserman Centre for Health Research, Mount Sinai Hospital, Toronto, Ontario, Canada
⨯
Mireia Musquera,

Affiliation Division of Urology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
⨯
Neil Fleshner,

Affiliation Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario, Canada
⨯
Vasundara Venkateswaran ,

* E-mail: vasundara.venkateswaran@sunnybrook.ca (VV); ozcelik@mshri.on.ca (HO)

Affiliation Division of Urology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
⨯
Hilmi Ozcelik

* E-mail: vasundara.venkateswaran@sunnybrook.ca (VV); ozcelik@mshri.on.ca (HO)

Affiliations Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
⨯

A Whole-Genome SNP Association Study of NCI60 Cell Line Panel Indicates a Role of Ca²⁺ Signaling in Selenium Resistance

Sevtap Savas,
Laurent Briollais,
Irada Ibrahim-zada,
Hamdi Jarjanazi,
Yun Hee Choi,
Mireia Musquera,
Neil Fleshner,
Vasundara Venkateswaran,
Hilmi Ozcelik

Published: September 7, 2010
https://doi.org/10.1371/journal.pone.0012601

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Selenium
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Prostate cancer
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Small interfering RNA
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Single nucleotide polymorphisms
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Transfection
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