CD8+ T Cells Cause Disability and Axon Loss in a Mouse Model of Multiple Sclerosis

Chandra Deb; Reghann G. LaFrance-Corey; William F. Schmalstieg; Brian M. Sauer; Huan Wang; Christopher L. German; Anthony J. Windebank; Moses Rodriguez; Charles L. Howe

doi:10.1371/journal.pone.0012478

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Peer-reviewed

Research Article

CD8⁺ T Cells Cause Disability and Axon Loss in a Mouse Model of Multiple Sclerosis

Chandra Deb ,

Contributed equally to this work with: Chandra Deb, Reghann G. LaFrance-Corey

Affiliation Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
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Reghann G. LaFrance-Corey ,

Contributed equally to this work with: Chandra Deb, Reghann G. LaFrance-Corey

Affiliation Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
⨯
William F. Schmalstieg,

Affiliation Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
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Brian M. Sauer,

Affiliation Neurobiology of Disease PhD Program, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
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Huan Wang,

Affiliation Neurosurgery, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
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Christopher L. German,

Affiliation Neurobiology of Disease PhD Program, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
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Anthony J. Windebank,

Affiliation Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
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Moses Rodriguez,

Affiliation Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
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Charles L. Howe

* E-mail: howe@mayo.edu

Affiliations Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America, Neuroscience, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America, Neurobiology of Disease PhD Program, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
⨯

CD8⁺ T Cells Cause Disability and Axon Loss in a Mouse Model of Multiple Sclerosis

Chandra Deb,
Reghann G. LaFrance-Corey,
William F. Schmalstieg,
Brian M. Sauer,
Huan Wang,
Christopher L. German,
Anthony J. Windebank,
Moses Rodriguez,
Charles L. Howe

Published: August 30, 2010
https://doi.org/10.1371/journal.pone.0012478

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Axons
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Cytotoxic T cells
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Adoptive transfer
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T cells
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Spinal cord
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Multiple sclerosis
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Neurons
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