Detection of Mycobacterium leprae DNA from Archaeological Skeletal Remains in Japan Using Whole Genome Amplification and Polymerase Chain Reaction

Koichi Suzuki; Wataru Takigawa; Kazunari Tanigawa; Kazuaki Nakamura; Yuko Ishido; Akira Kawashima; Huhehasi Wu; Takeshi Akama; Mariko Sue; Aya Yoshihara; Shuichi Mori; Norihisa Ishii

doi:10.1371/journal.pone.0012422

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Open Access

Peer-reviewed

Research Article

Detection of Mycobacterium leprae DNA from Archaeological Skeletal Remains in Japan Using Whole Genome Amplification and Polymerase Chain Reaction

Koichi Suzuki ,

* E-mail: koichis@nih.go.jp

Affiliation Laboratory of Molecular Diagnostics, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Wataru Takigawa,

Affiliation School of Rehabilitation Sciences at Fukuoka, International University of Health and Welfare, Fukuoka, Japan
⨯
Kazunari Tanigawa,

Affiliation Laboratory of Molecular Diagnostics, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Kazuaki Nakamura,

Affiliation Department of Pharmacology, National Research Institute for Child Health and Development, Tokyo, Japan
⨯
Yuko Ishido,

Affiliation Laboratory of Molecular Diagnostics, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Akira Kawashima,

Affiliation Laboratory of Molecular Diagnostics, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Huhehasi Wu,

Affiliation Laboratory of Molecular Diagnostics, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Takeshi Akama,

Affiliation Laboratory of Molecular Diagnostics, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Mariko Sue,

Affiliation Laboratory of Molecular Diagnostics, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Aya Yoshihara,

Affiliation Laboratory of Molecular Diagnostics, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Shuichi Mori,

Affiliation Laboratory of Molecular Epidemiology and Social Science, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Norihisa Ishii

Affiliation Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
⨯

Detection of Mycobacterium leprae DNA from Archaeological Skeletal Remains in Japan Using Whole Genome Amplification and Polymerase Chain Reaction

Koichi Suzuki,
Wataru Takigawa,
Kazunari Tanigawa,
Kazuaki Nakamura,
Yuko Ishido,
Akira Kawashima,
Huhehasi Wu,
Takeshi Akama,
Mariko Sue,
Aya Yoshihara

Published: August 26, 2010
https://doi.org/10.1371/journal.pone.0012422

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Mycobacterium leprae
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Polymerase chain reaction
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Ancient DNA
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Osteology
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Single nucleotide polymorphisms
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Leprosy
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Whole genome amplification
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Asia
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