Mutational Characterization of the Bile Acid Receptor TGR5 in Primary Sclerosing Cholangitis

• Johannes R. Hov ,

  * E-mail: j.e.r.hov@medisin.uio.no

  Affiliations Norwegian PSC Research Center, Clinic for Specialized Medicine and Surgery, Oslo University Hospital Rikshospitalet, Oslo, Norway, Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway, Institute of Clinical Medicine, University of Oslo, Oslo, Norway

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• Verena Keitel,

  Affiliation Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich-Heine-University, Düsseldorf, Germany

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• Jon K. Laerdahl,

  Affiliation Centre for Molecular Biology and Neuroscience and Institute of Medical Microbiology, Oslo University Hospital Rikshospitalet, Oslo, Norway

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• Lina Spomer,

  Affiliation Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich-Heine-University, Düsseldorf, Germany

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• Eva Ellinghaus,

  Affiliation Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany

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• Abdou ElSharawy,

  Affiliations Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany, First Department of Medicine, University Hospital Schleswig-Holstein, Kiel, Germany

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• Espen Melum,

  Affiliations Norwegian PSC Research Center, Clinic for Specialized Medicine and Surgery, Oslo University Hospital Rikshospitalet, Oslo, Norway, Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway, Institute of Clinical Medicine, University of Oslo, Oslo, Norway

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• Kirsten M. Boberg,

  Affiliation Norwegian PSC Research Center, Clinic for Specialized Medicine and Surgery, Oslo University Hospital Rikshospitalet, Oslo, Norway

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• Thomas Manke,

  Affiliation Max Planck Institute for Molecular Genetics, Berlin, Germany

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• Tobias Balschun,

  Affiliation Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany

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• Christoph Schramm,

  Affiliation 1st Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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• Annika Bergquist,

  Affiliation Department of Gastroenterology and Hepatology, Karolinska University Hospital Huddinge, Stockholm, Sweden

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• Tobias Weismüller,

  Affiliations Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany, Integrated Research and Treatment Center - Transplantation (IFB-Tx), Hannover Medical School, Hannover, Germany

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• Daniel Gotthardt,

  Affiliation Department of Medicine, University Hospital of Heidelberg, Heidelberg, Germany

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• Christian Rust,

  Affiliation Department of Medicine II, Grosshadern, University of Munich, Munich, Germany

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• Liesbet Henckaerts,

  Affiliation Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium

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• Clive M. Onnie,

  Affiliation Department of Medical and Molecular Genetics, King's College London School of Medicine, London, United Kingdom

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• Rinse K. Weersma,

  Affiliation Department of Gastroenterology and Hepatology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands

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• Martina Sterneck,

  Affiliation 1st Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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• Andreas Teufel,

  Affiliation 1st Department of Medicine, University of Mainz, Mainz, Germany

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• Heiko Runz,

  Affiliation Department of Human Genetics, University Hospital of Heidelberg, Heidelberg, Germany

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• Adolf Stiehl,

  Affiliation Department of Medicine, University Hospital of Heidelberg, Heidelberg, Germany

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• Cyriel Y. Ponsioen,

  Affiliation Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Cisca Wijmenga,

  Affiliation Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands

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• Morten H. Vatn,

  Affiliations Institute of Clinical Medicine, University of Oslo, Oslo, Norway, Institute of Clinical Epidemiology and Molecular Biology (Epigen), Akershus University Hospital, Lørenskog, Norway, Clinic for Specialized Medicine and Surgery, Oslo University Hospital Rikshospitalet, Oslo, Norway

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• for the IBSEN study group ,

  ¶Full list of members is available in Note S1.

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• Pieter C. F. Stokkers,

  Affiliation Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Severine Vermeire,

  Affiliation Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium

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• Christopher G. Mathew,

  Affiliation Department of Medical and Molecular Genetics, King's College London School of Medicine, London, United Kingdom

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• Benedicte A. Lie,

  Affiliation Institute of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway

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• Ulrich Beuers,

  Affiliation Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Michael P. Manns,

  Affiliations Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany, Integrated Research and Treatment Center - Transplantation (IFB-Tx), Hannover Medical School, Hannover, Germany

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• Stefan Schreiber,

  Affiliations Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany, First Department of Medicine, University Hospital Schleswig-Holstein, Kiel, Germany

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• Erik Schrumpf,

  Affiliations Norwegian PSC Research Center, Clinic for Specialized Medicine and Surgery, Oslo University Hospital Rikshospitalet, Oslo, Norway, Institute of Clinical Medicine, University of Oslo, Oslo, Norway

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• Dieter Häussinger,

  Affiliation Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich-Heine-University, Düsseldorf, Germany

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• Andre Franke,

  Affiliation Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany

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•  [ ... ],
• Tom H. Karlsen

  Affiliation Norwegian PSC Research Center, Clinic for Specialized Medicine and Surgery, Oslo University Hospital Rikshospitalet, Oslo, Norway

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