Insights into the Binding of Phenyltiocarbamide (PTC) Agonist to Its Target Human TAS2R38 Bitter Receptor

Xevi Biarnés; Alessandro Marchiori; Alejandro Giorgetti; Carmela Lanzara; Paolo Gasparini; Paolo Carloni; Stephan Born; Anne Brockhoff; Maik Behrens; Wolfgang Meyerhof

doi:10.1371/journal.pone.0012394

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Peer-reviewed

Research Article

Insights into the Binding of Phenyltiocarbamide (PTC) Agonist to Its Target Human TAS2R38 Bitter Receptor

Xevi Biarnés ,

Contributed equally to this work with: Xevi Biarnés, Alessandro Marchiori

Affiliation Statistical and Biological Physics, International School for Advanced Studies (SISSA-ISAS) and DEMOCRITOS (Modeling Center for research in atomistic Simulations), Trieste, Italy
⨯
Alessandro Marchiori ,

Contributed equally to this work with: Xevi Biarnés, Alessandro Marchiori

Affiliation Department of Reproductive and Developmental Sciences, University of Trieste, Trieste, Italy
⨯
Alejandro Giorgetti ,

* E-mail: alejandro.giorgetti@univr.it (AG); p.carloni@grs-sim.de (PC)

Affiliation Department of Biotechnology, University of Verona, Verona, Italy
⨯
Carmela Lanzara,

Affiliations Department of Reproductive and Developmental Sciences, University of Trieste, Trieste, Italy, Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, Trieste, Italy
⨯
Paolo Gasparini,

Affiliations Department of Reproductive and Developmental Sciences, University of Trieste, Trieste, Italy, Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, Trieste, Italy
⨯
Paolo Carloni ,

* E-mail: alejandro.giorgetti@univr.it (AG); p.carloni@grs-sim.de (PC)

Affiliations Statistical and Biological Physics, International School for Advanced Studies (SISSA-ISAS) and DEMOCRITOS (Modeling Center for research in atomistic Simulations), Trieste, Italy, Computational Biophysics, German Research School for Simulation Sciences, Aachen, Germany
⨯
Stephan Born,

Affiliation Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rebrücke (DIfE), Nuthetal, Germany
⨯
Anne Brockhoff,

Affiliation Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rebrücke (DIfE), Nuthetal, Germany
⨯
Maik Behrens,

Affiliation Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rebrücke (DIfE), Nuthetal, Germany
⨯
Wolfgang Meyerhof

Affiliation Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rebrücke (DIfE), Nuthetal, Germany
⨯

Insights into the Binding of Phenyltiocarbamide (PTC) Agonist to Its Target Human TAS2R38 Bitter Receptor

Xevi Biarnés,
Alessandro Marchiori,
Alejandro Giorgetti,
Carmela Lanzara,
Paolo Gasparini,
Paolo Carloni,
Stephan Born,
Anne Brockhoff,
Maik Behrens,
Wolfgang Meyerhof

Published: August 25, 2010
https://doi.org/10.1371/journal.pone.0012394

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