Integrin-Linked Kinase Is a Functional Mn2+-Dependent Protein Kinase that Regulates Glycogen Synthase Kinase-3β (GSK-3β) Phosphorylation

Mykola Maydan; Paul C. McDonald; Jasbinder Sanghera; Jun Yan; Charalampos Rallis; Sheena Pinchin; Gregory E. Hannigan; Leonard J. Foster; David Ish-Horowicz; Michael P. Walsh; Shoukat Dedhar

doi:10.1371/journal.pone.0012356

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Open Access

Peer-reviewed

Research Article

Integrin-Linked Kinase Is a Functional Mn²⁺-Dependent Protein Kinase that Regulates Glycogen Synthase Kinase-3β (GSK-3β) Phosphorylation

Mykola Maydan,

Affiliation Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, British Columbia, Canada
⨯
Paul C. McDonald,

Affiliation Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, British Columbia, Canada
⨯
Jasbinder Sanghera,

Affiliation SignalChem Inc., Richmond, British Columbia, Canada
⨯
Jun Yan,

Affiliation SignalChem Inc., Richmond, British Columbia, Canada
⨯
Charalampos Rallis,

Affiliations Developmental Genetics Laboratory, London Research Institute, London, United Kingdom, Department of Genetics, Evolution & Environment and UCL Cancer Institute, University College London, London, United Kingdom
⨯
Sheena Pinchin,

Affiliations Developmental Genetics Laboratory, London Research Institute, London, United Kingdom, Department of Genetics, Evolution & Environment and UCL Cancer Institute, University College London, London, United Kingdom
⨯
Gregory E. Hannigan,

Affiliation Centre for Cancer Research, Monash Institute of Medical Research, Melbourne, Victoria, Australia
⨯
Leonard J. Foster,

Affiliation Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada
⨯
David Ish-Horowicz,

Affiliation Developmental Genetics Laboratory, London Research Institute, London, United Kingdom
⨯
Michael P. Walsh,

Affiliation Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada
⨯
Shoukat Dedhar

* E-mail: sdedhar@bccrc.ca

Affiliations Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, British Columbia, Canada, Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada
⨯

Integrin-Linked Kinase Is a Functional Mn²⁺-Dependent Protein Kinase that Regulates Glycogen Synthase Kinase-3β (GSK-3β) Phosphorylation

Mykola Maydan,
Paul C. McDonald,
Jasbinder Sanghera,
Jun Yan,
Charalampos Rallis,
Sheena Pinchin,
Gregory E. Hannigan,
Leonard J. Foster,
David Ish-Horowicz,
Michael P. Walsh

Published: August 23, 2010
https://doi.org/10.1371/journal.pone.0012356

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