Are Cytochrome P450 CYP2C8 and CYP2C9 Polymorphisms Associated with Ibuprofen Response in Very Preterm Infants?

Xavier Durrmeyer; Shushanik Hovhannisyan; Yves Médard; Evelyne Jacqz-Aigrain; Fabrice Decobert; Jérome Barre; Corinne Alberti; Yannick Aujard; Claude Danan; Olivier Baud

doi:10.1371/journal.pone.0012329

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Peer-reviewed

Research Article

Are Cytochrome P450 CYP2C8 and CYP2C9 Polymorphisms Associated with Ibuprofen Response in Very Preterm Infants?

Xavier Durrmeyer ,

Contributed equally to this work with: Xavier Durrmeyer, Shushanik Hovhannisyan, Claude Danan, Olivier Baud

Affiliations Neonatal Intensive Care Unit, CHI Créteil, France, Fondation PremUP, Paris, France
⨯
Shushanik Hovhannisyan ,

Contributed equally to this work with: Xavier Durrmeyer, Shushanik Hovhannisyan, Claude Danan, Olivier Baud

Affiliations Neonatal Intensive Care Unit, Robert Debré Children's Hospital, Paris, France, Fondation PremUP, Paris, France
⨯
Yves Médard,

Affiliations Department of Pediatric Pharmacology and Pharmacogenetics, CIC INSERM 9202, Robert Debré Children's Hospital, Paris, France, Fondation PremUP, Paris, France
⨯
Evelyne Jacqz-Aigrain,

Affiliations Department of Pediatric Pharmacology and Pharmacogenetics, CIC INSERM 9202, Robert Debré Children's Hospital, Paris, France, Fondation PremUP, Paris, France
⨯
Fabrice Decobert,

Affiliations Neonatal Intensive Care Unit, CHI Créteil, France, Fondation PremUP, Paris, France
⨯
Jérome Barre,

Affiliations Clinical Researches Functional Unit, CHI Creteil, France, Fondation PremUP, Paris, France
⨯
Corinne Alberti,

Affiliations Clinical Epidemiology Unit, CIC-EC, Robert Debré Children's Hospital, Paris, France, Fondation PremUP, Paris, France
⨯
Yannick Aujard,

Affiliations Neonatal Intensive Care Unit, Robert Debré Children's Hospital, Paris, France, Fondation PremUP, Paris, France
⨯
Claude Danan ,

Contributed equally to this work with: Xavier Durrmeyer, Shushanik Hovhannisyan, Claude Danan, Olivier Baud

Affiliations Neonatal Intensive Care Unit, CHI Créteil, France, Fondation PremUP, Paris, France
⨯
Olivier Baud

Contributed equally to this work with: Xavier Durrmeyer, Shushanik Hovhannisyan, Claude Danan, Olivier Baud

* E-mail: olivier.baud@rdb.aphp.fr

Affiliations Neonatal Intensive Care Unit, Robert Debré Children's Hospital, Paris, France, Fondation PremUP, Paris, France
⨯

Are Cytochrome P450 CYP2C8 and CYP2C9 Polymorphisms Associated with Ibuprofen Response in Very Preterm Infants?

Xavier Durrmeyer,
Shushanik Hovhannisyan,
Yves Médard,
Evelyne Jacqz-Aigrain,
Fabrice Decobert,
Jérome Barre,
Corinne Alberti,
Yannick Aujard,
Claude Danan,
Olivier Baud

Published: August 23, 2010
https://doi.org/10.1371/journal.pone.0012329

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