Granuloma Formation and Host Defense in Chronic Mycobacterium tuberculosis Infection Requires PYCARD/ASC but Not NLRP3 or Caspase-1

Erin McElvania TeKippe; Irving C. Allen; Paul D. Hulseberg; Jonathan T. Sullivan; Jessica R. McCann; Matyas Sandor; Miriam Braunstein; Jenny P.-Y. Ting

doi:10.1371/journal.pone.0012320

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Peer-reviewed

Research Article

Granuloma Formation and Host Defense in Chronic Mycobacterium tuberculosis Infection Requires PYCARD/ASC but Not NLRP3 or Caspase-1

Erin McElvania TeKippe,

Affiliation Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Irving C. Allen,

Affiliation Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Paul D. Hulseberg,

Affiliation Department of Pathology and Laboratory Medicine and Cellular and Molecular Pathology Program, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America
⨯
Jonathan T. Sullivan,

Affiliation Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Jessica R. McCann,

Affiliation Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Matyas Sandor,

Affiliation Department of Pathology and Laboratory Medicine and Cellular and Molecular Pathology Program, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America
⨯
Miriam Braunstein ,

Contributed equally to this work with: Miriam Braunstein, Jenny P.-Y. Ting

Affiliation Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Jenny P.-Y. Ting

Contributed equally to this work with: Miriam Braunstein, Jenny P.-Y. Ting

* E-mail: panyun@med.unc.edu

Affiliations Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯

Granuloma Formation and Host Defense in Chronic Mycobacterium tuberculosis Infection Requires PYCARD/ASC but Not NLRP3 or Caspase-1

Erin McElvania TeKippe,
Irving C. Allen,
Paul D. Hulseberg,
Jonathan T. Sullivan,
Jessica R. McCann,
Matyas Sandor,
Miriam Braunstein,
Jenny P.-Y. Ting

Published: August 20, 2010
https://doi.org/10.1371/journal.pone.0012320

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