Thymoquinone Induces Telomere Shortening, DNA Damage and Apoptosis in Human Glioblastoma Cells

Resham Lal Gurung; Shi Ni Lim; Aik Kia Khaw; Jasmine Fen Fen Soon; Kirthan Shenoy; Safiyya Mohamed Ali; Manikandan Jayapal; Swaminathan Sethu; Rajamanickam Baskar; M. Prakash Hande

doi:10.1371/journal.pone.0012124

Loading metrics

Open Access

Peer-reviewed

Research Article

Thymoquinone Induces Telomere Shortening, DNA Damage and Apoptosis in Human Glioblastoma Cells

Resham Lal Gurung,

Affiliation Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⨯
Shi Ni Lim,

Affiliation Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⨯
Aik Kia Khaw,

Affiliation Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⨯
Jasmine Fen Fen Soon,

Affiliation Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⨯
Kirthan Shenoy,

Affiliation Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⨯
Safiyya Mohamed Ali,

Affiliation Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⨯
Manikandan Jayapal,

Affiliation Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⨯
Swaminathan Sethu,

Affiliation Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⨯
Rajamanickam Baskar,

Affiliation Division of Cellular and Molecular Research, Department of Radiation Oncology, National Cancer Centre, Singapore, Singapore
⨯
M. Prakash Hande

* E-mail: phsmph@nus.edu.sg

Affiliation Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⨯

Thymoquinone Induces Telomere Shortening, DNA Damage and Apoptosis in Human Glioblastoma Cells

Resham Lal Gurung,
Shi Ni Lim,
Aik Kia Khaw,
Jasmine Fen Fen Soon,
Kirthan Shenoy,
Safiyya Mohamed Ali,
Manikandan Jayapal,
Swaminathan Sethu,
Rajamanickam Baskar,
M. Prakash Hande

Published: August 12, 2010
https://doi.org/10.1371/journal.pone.0012124

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Glioblastoma cells
Is the Subject Area "Glioblastoma cells" applicable to this article?

Thanks for your feedback.
Telomeres
Is the Subject Area "Telomeres" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
DNA damage
Is the Subject Area "DNA damage" applicable to this article?

Thanks for your feedback.
Telomere length
Is the Subject Area "Telomere length" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
DNA repair
Is the Subject Area "DNA repair" applicable to this article?

Thanks for your feedback.
Breast cancer
Is the Subject Area "Breast cancer" applicable to this article?

Thanks for your feedback.