Transgenic Overexpression of Active Calcineurin in β-Cells Results in Decreased β-Cell Mass and Hyperglycemia

Open Access

Peer-reviewed

Research Article

Ernesto Bernal-Mizrachi ,

* E-mail: ebernal@umich.edu

Affiliation Division of Metabolism, Endocrinology, Diabetes, The Brehm Center for Type 1 Diabetes, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Corentin Cras-Méneur,

Affiliation Division of Metabolism, Endocrinology, Diabetes, The Brehm Center for Type 1 Diabetes, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Bo Ra Ye,

Affiliation Division of Metabolism, Endocrinology, Diabetes, The Brehm Center for Type 1 Diabetes, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
James D. Johnson,

Affiliation Department of Cellular and Physiological Sciences, Department of Surgery, University of British Columbia, Vancouver, Canada
⨯
M. Alan Permutt

Affiliation Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯

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Insulin secretion
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Glucose
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Insulin
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Apoptosis
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Calcineurin signaling cascade
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Glucose signaling
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Genetically modified animals
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Morphometry
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