In Vivo Delivery of Gremlin siRNA Plasmid Reveals Therapeutic Potential against Diabetic Nephropathy by Recovering Bone Morphogenetic Protein-7

Qingxian Zhang; Yonghong Shi; Jun Wada; Sandra M. Malakauskas; Maodong Liu; Yunzhuo Ren; Chunyang Du; Huijun Duan; Yingmin Li; Ying Li; Yanling Zhang

doi:10.1371/journal.pone.0011709

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Open Access

Peer-reviewed

Research Article

In Vivo Delivery of Gremlin siRNA Plasmid Reveals Therapeutic Potential against Diabetic Nephropathy by Recovering Bone Morphogenetic Protein-7

Qingxian Zhang ,

Contributed equally to this work with: Qingxian Zhang, Yonghong Shi

Affiliation Department of Nephrology, Third Hospital, Hebei Medical University, Shijiazhuang, China
⨯
Yonghong Shi ,

Contributed equally to this work with: Qingxian Zhang, Yonghong Shi

Affiliation Department of Pathology, Hebei Medical University, Shijiazhuang, China
⨯
Jun Wada,

Affiliation Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Okayama, Japan
⨯
Sandra M. Malakauskas,

Affiliation Division of Nephrology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Maodong Liu,

Affiliation Department of Nephrology, Third Hospital, Hebei Medical University, Shijiazhuang, China
⨯
Yunzhuo Ren,

Affiliation Department of Pathology, Hebei Medical University, Shijiazhuang, China
⨯
Chunyang Du,

Affiliation Department of Pathology, Hebei Medical University, Shijiazhuang, China
⨯
Huijun Duan,

Affiliation Department of Pathology, Hebei Medical University, Shijiazhuang, China
⨯
Yingmin Li,

Affiliation Department of Pathology, Hebei Medical University, Shijiazhuang, China
⨯
Ying Li,

Affiliation Department of Nephrology, Third Hospital, Hebei Medical University, Shijiazhuang, China
⨯
Yanling Zhang

* E-mail: zhang2199@126.com

Current address: Keenan Research Centre in the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada

Affiliation Department of Nephrology, Third Hospital, Hebei Medical University, Shijiazhuang, China
⨯

In Vivo Delivery of Gremlin siRNA Plasmid Reveals Therapeutic Potential against Diabetic Nephropathy by Recovering Bone Morphogenetic Protein-7

Qingxian Zhang,
Yonghong Shi,
Jun Wada,
Sandra M. Malakauskas,
Maodong Liu,
Yunzhuo Ren,
Chunyang Du,
Huijun Duan,
Yingmin Li,
Ying Li

Published: July 22, 2010
https://doi.org/10.1371/journal.pone.0011709

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