Co-Depletion of Cathepsin B and uPAR Induces G0/G1 Arrest in Glioma via FOXO3a Mediated p27Kip1 Upregulation

Sreelatha Gopinath; Rama Rao Malla; Christopher S. Gondi; Kiranmai Alapati; Daniel Fassett; Jeffrey D. Klopfenstein; Dzung H. Dinh; Meena Gujrati; Jasti S. Rao

doi:10.1371/journal.pone.0011668

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Peer-reviewed

Research Article

Co-Depletion of Cathepsin B and uPAR Induces G0/G1 Arrest in Glioma via FOXO3a Mediated p27^Kip1 Upregulation

Sreelatha Gopinath,

Affiliation Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
⨯
Rama Rao Malla,

Affiliation Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
⨯
Christopher S. Gondi,

Affiliation Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
⨯
Kiranmai Alapati,

Affiliation Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
⨯
Daniel Fassett,

Affiliation Department of Neurosurgery, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
⨯
Jeffrey D. Klopfenstein,

Affiliation Department of Neurosurgery, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
⨯
Dzung H. Dinh,

Affiliation Department of Neurosurgery, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
⨯
Meena Gujrati,

Affiliation Department of Pathology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
⨯
Jasti S. Rao

* E-mail: jsrao@uic.edu

Affiliations Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America, Department of Neurosurgery, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
⨯

Co-Depletion of Cathepsin B and uPAR Induces G0/G1 Arrest in Glioma via FOXO3a Mediated p27^Kip1 Upregulation

Sreelatha Gopinath,
Rama Rao Malla,
Christopher S. Gondi,
Kiranmai Alapati,
Daniel Fassett,
Jeffrey D. Klopfenstein,
Dzung H. Dinh,
Meena Gujrati,
Jasti S. Rao

Published: July 22, 2010
https://doi.org/10.1371/journal.pone.0011668

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