All-Trans Retinoic Acid Directs Urothelial Specification of Murine Embryonic Stem Cells via GATA4/6 Signaling Mechanisms

Joshua R. Mauney; Aruna Ramachandran; Richard N. Yu; George Q. Daley; Rosalyn M. Adam; Carlos R. Estrada

doi:10.1371/journal.pone.0011513

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Research Article

All-Trans Retinoic Acid Directs Urothelial Specification of Murine Embryonic Stem Cells via GATA4/6 Signaling Mechanisms

Joshua R. Mauney,

Affiliations Urological Diseases Research Center, Children's Hospital Boston, Boston, Massachusetts, United States of America, Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Aruna Ramachandran,

Affiliations Urological Diseases Research Center, Children's Hospital Boston, Boston, Massachusetts, United States of America, Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Richard N. Yu,

Affiliations Urological Diseases Research Center, Children's Hospital Boston, Boston, Massachusetts, United States of America, Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
George Q. Daley,

Affiliations Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America, Harvard Stem Cell Institute, Boston, Massachusetts, United States of America, Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Children's Hospital Boston, Boston, Massachusetts, United States of America, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Boston, Massachusetts, United States of America, Division of Hematology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Manton Center for Orphan Disease Research, Boston, Massachusetts, United States of America
⨯
Rosalyn M. Adam ,

Contributed equally to this work with: Rosalyn M. Adam, Carlos R. Estrada

* E-mail: carlos.estrada@childrens.harvard.edu (CRE); rosalyn.adam@childrens.harvard.edu (RMA)

Affiliations Urological Diseases Research Center, Children's Hospital Boston, Boston, Massachusetts, United States of America, Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Carlos R. Estrada

Contributed equally to this work with: Rosalyn M. Adam, Carlos R. Estrada

* E-mail: carlos.estrada@childrens.harvard.edu (CRE); rosalyn.adam@childrens.harvard.edu (RMA)

Affiliations Urological Diseases Research Center, Children's Hospital Boston, Boston, Massachusetts, United States of America, Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

All-Trans Retinoic Acid Directs Urothelial Specification of Murine Embryonic Stem Cells via GATA4/6 Signaling Mechanisms

Joshua R. Mauney,
Aruna Ramachandran,
Richard N. Yu,
George Q. Daley,
Rosalyn M. Adam,
Carlos R. Estrada

Published: July 13, 2010
https://doi.org/10.1371/journal.pone.0011513

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Bladder
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Urothelium
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Endoderm
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Cell differentiation
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