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Open Access

Peer-reviewed

Research Article

Loss of Androgen Receptor-Dependent Growth Suppression by Prostate Cancer Cells Can Occur Independently from Acquiring Oncogenic Addiction to Androgen Receptor Signaling

Jason M. D'Antonio ,

* E-mail: jdanton1@jhmi.edu (JMD); isaacjo@jhmi.edu (JTI)

Affiliations Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Urology, The Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Donald J. Vander Griend,

Affiliations Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Urology, The Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Surgery, The University of Chicago, Chicago, Illinois, United States of America
⨯
Lizamma Antony,

Affiliation Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
George Ndikuyeze,

Affiliation Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Susan L. Dalrymple,

Affiliation Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Shahriar Koochekpour,

Affiliation Departments of Biochemistry and Molecular Biology, Urology, Stanley S. Scott Cancer Center, Louisiana State University-Health Sciences Center, New Orleans, Louisiana, United States of America
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John T. Isaacs

* E-mail: jdanton1@jhmi.edu (JMD); isaacjo@jhmi.edu (JTI)

Affiliations Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Urology, The Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯

Loss of Androgen Receptor-Dependent Growth Suppression by Prostate Cancer Cells Can Occur Independently from Acquiring Oncogenic Addiction to Androgen Receptor Signaling

Jason M. D'Antonio,
Donald J. Vander Griend,
Lizamma Antony,
George Ndikuyeze,
Susan L. Dalrymple,
Shahriar Koochekpour,
John T. Isaacs

x

Published: July 8, 2010
https://doi.org/10.1371/journal.pone.0011475

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Prostate cancer
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Androgens
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Polymerase chain reaction
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Signal amplification
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Oncogenic signaling
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Genetically modified animals
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Mutation
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Protein expression
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