Themis2/ICB1 Is a Signaling Scaffold That Selectively Regulates Macrophage Toll-Like Receptor Signaling and Cytokine Production

Matthew J. Peirce; Matthew Brook; Nicholas Morrice; Robert Snelgrove; Shajna Begum; Alessandra Lanfrancotti; Clare Notley; Tracy Hussell; Andrew P. Cope; Robin Wait

doi:10.1371/journal.pone.0011465

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Peer-reviewed

Research Article

Themis2/ICB1 Is a Signaling Scaffold That Selectively Regulates Macrophage Toll-Like Receptor Signaling and Cytokine Production

Matthew J. Peirce ,

* E-mail: m.pierce@imperial.ac.uk

Affiliation Kennedy Institute of Rheumatology Division, Imperial College London, London, United Kingdom
⨯
Matthew Brook,

Current address: MRC Human Reproductive Sciences Unit, Queen's Medical Research Institute, Edinburgh, United Kingdom

Affiliation Kennedy Institute of Rheumatology Division, Imperial College London, London, United Kingdom
⨯
Nicholas Morrice,

Affiliation MRC Protein Phosphorylation Unit, University of Dundee, Dundee, United Kingdom
⨯
Robert Snelgrove,

Current address: National Heart and Lung Institute, Imperial College London, London, United Kingdom

Affiliation Kennedy Institute of Rheumatology Division, Imperial College London, London, United Kingdom
⨯
Shajna Begum,

Affiliation Kennedy Institute of Rheumatology Division, Imperial College London, London, United Kingdom
⨯
Alessandra Lanfrancotti,

Affiliation Kennedy Institute of Rheumatology Division, Imperial College London, London, United Kingdom
⨯
Clare Notley,

Current address: Centre for Rheumatology, University College London, London, United Kingdom

Affiliation Kennedy Institute of Rheumatology Division, Imperial College London, London, United Kingdom
⨯
Tracy Hussell,

Current address: National Heart and Lung Institute, Imperial College London, London, United Kingdom

Affiliation Kennedy Institute of Rheumatology Division, Imperial College London, London, United Kingdom
⨯
Andrew P. Cope ,

Contributed equally to this work with: Andrew P. Cope, Robin Wait

Current address: Academic Department of Rheumatology, King's College London School of Medicine, London, United Kingdom

Affiliation Kennedy Institute of Rheumatology Division, Imperial College London, London, United Kingdom
⨯
Robin Wait

Contributed equally to this work with: Andrew P. Cope, Robin Wait

Affiliation Kennedy Institute of Rheumatology Division, Imperial College London, London, United Kingdom
⨯

Themis2/ICB1 Is a Signaling Scaffold That Selectively Regulates Macrophage Toll-Like Receptor Signaling and Cytokine Production

Matthew J. Peirce,
Matthew Brook,
Nicholas Morrice,
Robert Snelgrove,
Shajna Begum,
Alessandra Lanfrancotti,
Clare Notley,
Tracy Hussell,
Andrew P. Cope,
Robin Wait

Published: July 13, 2010
https://doi.org/10.1371/journal.pone.0011465

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Macrophages
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Tyrosine
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Immunoprecipitation
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Phosphorylation
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Protein expression
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Transfection
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ERK signaling cascade
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Toll-like receptors
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