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Open Access
Peer-reviewed
Research Article
A53T-Alpha-Synuclein Overexpression Impairs Dopamine Signaling and Striatal Synaptic Plasticity in Old Mice
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Alexander Kurz,
Affiliation Department of Neurology, Goethe University Medical School, Frankfurt, Germany
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Kay L. Double,
Affiliation Neuroscience Research Australia and the University of New South Wales, Sydney, Australia
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Isabel Lastres-Becker,
Current address: Departamento de Bioquímica, Instituto de Investigaciones Biomédicas “Alberto Sols”, and Centro de Investigación en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Affiliation Department of Neurology, Goethe University Medical School, Frankfurt, Germany
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Alessandro Tozzi,
Affiliations Clinica Neurologica, Università di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy, Fondazione Santa Lucia I.R.C.C.S.-C.E.R.C., European Brain Research Institute, Roma, Italy
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Michela Tantucci,
Affiliation Clinica Neurologica, Università di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy
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Vanessa Bockhart,
Affiliation Molecular Psychopharmacology, Department of Psychiatry, Johannes Gutenberg University, Mainz, Germany
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Michael Bonin,
Affiliation Department Medical Genetics, University of Tübingen, Tübingen, Germany
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Moisés García-Arencibia,
Affiliation Department of Biochemistry and Molecular Biology and “Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED)”, Faculty of Medicine, Complutense University, Madrid, Spain
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Silke Nuber,
Affiliation Department of Medical Genetics, University of Tübingen, Tübingen, Germany
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Falk Schlaudraff,
Affiliation Institute of General Physiology, University of Ulm, Ulm, Germany
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Birgit Liss,
Affiliation Institute of General Physiology, University of Ulm, Ulm, Germany
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Javier Fernández-Ruiz,
Affiliation Department of Biochemistry and Molecular Biology and “Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED)”, Faculty of Medicine, Complutense University, Madrid, Spain
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Manfred Gerlach,
Affiliation Laboratory for Clinical Neurochemistry, Department Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Bayerische Julius-Maximilian-Universität, Würzburg, Germany
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Ullrich Wüllner,
Affiliation Department of Neurology, Rheinische Friedrich Wilhelms Universität, Bonn, Germany
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Hartmut Lüddens,
Affiliation Molecular Psychopharmacology, Department of Psychiatry, Johannes Gutenberg University, Mainz, Germany
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Paolo Calabresi,
Affiliations Clinica Neurologica, Università di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy, Fondazione Santa Lucia I.R.C.C.S.-C.E.R.C., European Brain Research Institute, Roma, Italy
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Georg Auburger,
Affiliation Department of Neurology, Goethe University Medical School, Frankfurt, Germany
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Suzana Gispert
* E-mail: gispert-sanchez@em.uni-frankfurt.de
Affiliation Department of Neurology, Goethe University Medical School, Frankfurt, Germany
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A53T-Alpha-Synuclein Overexpression Impairs Dopamine Signaling and Striatal Synaptic Plasticity in Old Mice
- Alexander Kurz,
- Kay L. Double,
- Isabel Lastres-Becker,
- Alessandro Tozzi,
- Michela Tantucci,
- Vanessa Bockhart,
- Michael Bonin,
- Moisés García-Arencibia,
- Silke Nuber,
- Falk Schlaudraff
- Published: July 7, 2010
- https://doi.org/10.1371/journal.pone.0011464