Iterative Structure-Based Peptide-Like Inhibitor Design against the Botulinum Neurotoxin Serotype A

Jorge E. Zuniga; Jared T. Hammill; Omri Drory; Jonathan E. Nuss; James C. Burnett; Rick Gussio; Peter Wipf; Sina Bavari; Axel T. Brunger

doi:10.1371/journal.pone.0011378

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Peer-reviewed

Research Article

Iterative Structure-Based Peptide-Like Inhibitor Design against the Botulinum Neurotoxin Serotype A

Jorge E. Zuniga,

Affiliation Howard Hughes Medical Institute and Departments of Molecular and Cellular Physiology, Neurology and Neurological Science, Structural Biology, and Photon Science, Stanford University, Stanford, California, United States of America
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Jared T. Hammill,

Affiliation Center for Chemical Methodologies and Library Development, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Omri Drory,

Affiliation Howard Hughes Medical Institute and Departments of Molecular and Cellular Physiology, Neurology and Neurological Science, Structural Biology, and Photon Science, Stanford University, Stanford, California, United States of America
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Jonathan E. Nuss,

Affiliation Division of Bacteriology, Department of Immunology, Target Identification, and Translational Research, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
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James C. Burnett,

Affiliation Target Structure-Based Drug Discovery Group, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
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Rick Gussio,

Affiliation Information Technology Branch, Developmental Therapeutics Program, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
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Peter Wipf ,

* E-mail: pwipf@pitt.edu (PW); brunger@stanford.edu (ATB)

Affiliation Center for Chemical Methodologies and Library Development, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Sina Bavari,

Affiliation Division of Bacteriology, Department of Immunology, Target Identification, and Translational Research, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
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Axel T. Brunger

* E-mail: pwipf@pitt.edu (PW); brunger@stanford.edu (ATB)

Affiliation Howard Hughes Medical Institute and Departments of Molecular and Cellular Physiology, Neurology and Neurological Science, Structural Biology, and Photon Science, Stanford University, Stanford, California, United States of America
⨯

Iterative Structure-Based Peptide-Like Inhibitor Design against the Botulinum Neurotoxin Serotype A

Jorge E. Zuniga,
Jared T. Hammill,
Omri Drory,
Jonathan E. Nuss,
James C. Burnett,
Rick Gussio,
Peter Wipf,
Sina Bavari,
Axel T. Brunger

Published: June 30, 2010
https://doi.org/10.1371/journal.pone.0011378

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