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Open Access
Peer-reviewed
Research Article
Liposome-siRNA-Peptide Complexes Cross the Blood-Brain Barrier and Significantly Decrease PrPC on Neuronal Cells and PrPRES in Infected Cell Cultures
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Bruce Pulford,
Affiliation Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America
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Natalia Reim,
Affiliation Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America
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Aimee Bell,
Affiliation Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America
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Jessica Veatch,
Affiliation Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America
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Genevieve Forster,
Affiliation Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America
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Heather Bender,
Affiliation Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America
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Crystal Meyerett,
Affiliation Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America
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Scott Hafeman,
Affiliation Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America
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Brady Michel,
Affiliation Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America
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Theodore Johnson,
Affiliation Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America
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A. Christy Wyckoff,
Affiliation Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America
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Gino Miele,
Affiliation Pfizer Global Research & Development, Translational Medicine Research Collaboration, Dundee, Scotland
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Christian Julius,
Affiliation Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America
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Jan Kranich,
Affiliation Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
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Alan Schenkel,
Affiliation Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America
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Steven Dow,
Affiliation Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America
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Mark D. Zabel
* E-mail: mark.zabel@colostate.edu
Affiliation Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America
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Liposome-siRNA-Peptide Complexes Cross the Blood-Brain Barrier and Significantly Decrease PrPC on Neuronal Cells and PrPRES in Infected Cell Cultures
- Bruce Pulford,
- Natalia Reim,
- Aimee Bell,
- Jessica Veatch,
- Genevieve Forster,
- Heather Bender,
- Crystal Meyerett,
- Scott Hafeman,
- Brady Michel,
- Theodore Johnson
- Published: June 14, 2010
- https://doi.org/10.1371/journal.pone.0011085