Multiple Loss-of-Function Mechanisms Contribute to SCN5A-Related Familial Sick Sinus Syndrome

• Junhong Gui ,

  Contributed equally to this work with: Junhong Gui, Tao Wang

  Affiliation Cardiovascular and Genetic Medicine Research Groups, School of Biomedicine, University of Manchester, Manchester, United Kingdom

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• Tao Wang ,

  Contributed equally to this work with: Junhong Gui, Tao Wang

  Affiliation Cardiovascular and Genetic Medicine Research Groups, School of Biomedicine, University of Manchester, Manchester, United Kingdom

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• Richard P. O. Jones,

  Affiliation Cardiovascular and Genetic Medicine Research Groups, School of Biomedicine, University of Manchester, Manchester, United Kingdom

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• Dorothy Trump,

  Affiliation Cardiovascular and Genetic Medicine Research Groups, School of Biomedicine, University of Manchester, Manchester, United Kingdom

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• Thomas Zimmer ,

  * E-mail: thomas.zimmer@mti.uni-jena.de (TZ); ming.lei@manchester.ac.uk (ML)

  Affiliation Institute of Physiology II, Friedrich Schiller University, Jena, Germany

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• Ming Lei

  * E-mail: thomas.zimmer@mti.uni-jena.de (TZ); ming.lei@manchester.ac.uk (ML)

  Affiliation Cardiovascular and Genetic Medicine Research Groups, School of Biomedicine, University of Manchester, Manchester, United Kingdom

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